| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Hard tissue adhesive drug delivery system based on phosphorylated pullulan has developed. Elucidation of the complex formation mechanism and Control of drug release of phosphorylated pullulan and cationic surfactants was reported. Relationship between complex formation and pH, degree of substitution, ionic-strength indicated that neutralization of charge between phosphate group and cation and hydrophobic interaction has important role in complex formation.
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