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Creation of a novel device for renal regeneration by the interaction of a nonwoven filters and cells.

Research Project

Project/Area Number 25410232
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Polymer/Textile materials
Research InstitutionFujita Health University

Principal Investigator

HORI Hideo  藤田保健衛生大学, 保健学研究科, 講師 (00342113)

Co-Investigator(Kenkyū-buntansha) HIKI Yoshiyuki  藤田保健衛生大学, 医療科学部, 教授 (20156566)
KITAGUCHI Nobuya  藤田保健衛生大学, 医療科学部, 教授 (70508077)
SHINZATO Masanori  藤田保健衛生大学, 医療科学部, 准教授 (80148288)
Research Collaborator NAGAO Shizuko  藤田保健衛生大学, 疾患モデル教育研究センター, 教授
NIIMI Gen  藤田保健衛生大学, 共同利用研究施設, 講師
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords再生医療 / 不織布 / 腎臓 / 幹細胞 / 成長因子
Outline of Final Research Achievements

We investigated the design of the cell capturing device, growth factor production by the cells on nonwoven filters, and therapeutic effect of cells capturing nonwoven filters on a rat model of chronic renal failure.
1.The Nonwoven filters diameter less than 3 μm and the number of filter disks were necessary to capture Cells at high rates. The production of growth factor was significantly enhanced by the interaction with nonwoven filters. These enhancements varied with the combination of the nonwoven filter and cells.
2.Rat mesenchymal stem cells on nonwoven filters provide enhanced hepatocyte growth factor production and reduced glomerulosclerotic lesions in a model of chronic renal failure.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A novel cell-coutaining device for regenerative medicine:biodegradable nonwoven filters with peripheral blood cells promote wound healing2015

    • Author(s)
      U Iwamoto, H Hori, Y Takami, Y Tokushima, M Shinzato, M Yasutake, N Kitaguchi.
    • Journal Title

      J Artif Organs

      Volume: 18 Issue: 4 Pages: 315-321

    • DOI

      10.1007/s10047-015-0845-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Appropriate nonwoven filters effectively capture human peripheral blood cells and mesenchymal stem cells, which show enhanced production of growth factors.2015

    • Author(s)
      Hideo Hori, Ushio Iwamoto, Gen Niimi, Masanori Shinzato, Yoshiyuki Hiki, Yasuo Tokushima, Kazunori Kawaguchi, Atsushi Ohashi, Shigeru Nakai, Mikitomo Yasutake, Nobuya Kitaguchi.
    • Journal Title

      J Artif Organs

      Volume: 18 Issue: 1 Pages: 55-63

    • DOI

      10.1007/s10047-014-0794-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 組織再生促進デバイス:細胞と不織布粉体との混合物による成長因子産生能の検討2015

    • Author(s)
      堀秀生、兼子結衣、大野朱香、佐藤綾乃、中谷友樹、新美元、比企能之、北口暢哉
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Therapeutic Effect of Nonwoven Biodegradable Filters with Mesenchymal Stem Cells on a Rat Model of Chronic Renal Failure.2014

    • Author(s)
      H. Hori, M. Shinzato, K. Kawaguchi, A. Ohashi, S. Nakai, S. Nagao, Y. Hiki, N. Kitaguchi.
    • Organizer
      41st Annual ESAO Congress
    • Place of Presentation
      Rome, Italy.
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] THERAPEUTIC EFFECT OF NONWOVEN BIODEGRADABLE FILTERS WITH MESENCHYMAL STEM CELLS ON A RAT MODEL OF CHRONIC RENAL FAILURE2014

    • Author(s)
      H Hori , M Shinzato , K Kawaguchi , A Ohashi , S Nakai , S Nagao , Y Hiki , N Kitaguchi
    • Organizer
      41th Annual ESAO congress
    • Place of Presentation
      ROMA, ITALY
    • Related Report
      2013 Research-status Report
  • [Presentation] Therapeutic effect of nonwoven polyester filters with/without peripheral-blood cells on a rat model of chronic renal failure2013

    • Author(s)
      Hideo Hori, Masanori Shinzato, Taiga Ishida, Emi Takase, Kazunori Kawaguchi, Atsushi Ohashi, Shigeru Nakai, Shizuko Nagao, Yoshiyuki Hiki , Nobuya Kitaguchi
    • Organizer
      5th Congress of the International Federation for Artificial Organs
    • Place of Presentation
      YOKOHAMA
    • Related Report
      2013 Research-status Report
  • [Presentation] 生分解性不織布を足場材料とする再生医療デバイス~腎再生を目指して~2013

    • Author(s)
      北口暢哉、堀秀生
    • Organizer
      中部地区 医療・バイオ系シーズ発表会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 組織修復及び/又は再生促進剤2013

    • Inventor(s)
      北口暢哉、堀秀生
    • Industrial Property Rights Holder
      北口暢哉、堀秀生
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-256119
    • Filing Date
      2013-12-11
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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