| Project/Area Number |
25420036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Kanazawa Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 骨再生医療用生体吸収性材料 / ハイドロキシアパタイト / 生体吸収性ポリマー / 界面制御 / 破骨細胞 / 細胞挙動制御 |
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| Outline of Final Research Achievements |
In this study, the hybrid-interface control was applied to the interface between hydroxyapatite and bioabsorbable polymer. By control of the interface-control ratio, it was made possible to create hydroxyapatite/bioabsorbable polymer composite scaffold, which can improve the fracture and hydrolysis properties. Then, polycaprolactone was chosen as a bioabsorbable polymer, where hybrid-interface control can be applied and which can be dissolved by osteoclasts. It was suggested that osteoclastic metabolic behavior can be controlled by the control of the substrate elastic modulus. In addition, it was suggested that the microstructure, where both osteoblasts and osteoclasts can be controlled, can be designed by combination of hydroxyapatite and carbonate apatite.
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