Investigation of a Dynamic Mechanosensing System by Measuring Natural Modes of Vibration of a Cell
| Project/Area Number |
25420179
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dynamics/Control
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| Research Institution | Yokohama National University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 機械力学・制御 / 細胞 / 骨 / 振動学 / 振動モード / 固有振動数 / モデル化 / 力学センサ |
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| Outline of Final Research Achievements |
This report describes the micron-sized measurement of natural modes of vibration of a cell under mechanical vibration and the relationship between local deformation and biochemical reaction in a cell. As a result, we developed the experimental system for the measurement of natural modes of vibration for a living cell and confirmed its feasibility. Furthermore, we measured the relationship between the displacement of actin cytoskeletons and the maximum value of the change rate of calcium ion concentration of a cell. This indicates that the mechanical sensing system of a cell is partially clarified.
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Report
(4 results)
Research Products
(30 results)
