Control of BAp orientatio in mandible with the masticatory disturbance using gene-deleted pathological mice.
| Project/Area Number |
25420754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural/Functional materials
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| Research Institution | Osaka University |
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Principal Investigator |
FUJITANI WATARU 大阪大学, 工学(系)研究科(研究院), 技術専門職員 (90379149)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANO Takayoshi 大阪大学, 大学院工学研究科, 教授 (30243182)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生体アパタイト / 配向性 / 下顎骨 / 咀嚼障害 / 微小領域X線回折 / 骨系細胞 |
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| Outline of Final Research Achievements |
In this research, we analyzed the biological apatite (BAp) c-axis orientation in the mandible of the c-src KO mice with osteoclast-malfunction utilizing the microbeam X-ray diffraction technique. In comparison with the control mice, the c-src KO mice showed a low degree of BAp orientation and reduced bone mineral density (BMD). The degree of BAp c-axis orientation rather than BMD largely correlated with the Young's modulus. Thus, it is suggested that the osteoclast malfunction had significant effects on bone microstructure and mechanical function.
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Report
(4 results)
Research Products
(13 results)
