| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this research, we analyzed the biological apatite (BAp) c-axis orientation in the mandible of the c-src KO mice with osteoclast-malfunction utilizing the microbeam X-ray diffraction technique. In comparison with the control mice, the c-src KO mice showed a low degree of BAp orientation and reduced bone mineral density (BMD). The degree of BAp c-axis orientation rather than BMD largely correlated with the Young's modulus. Thus, it is suggested that the osteoclast malfunction had significant effects on bone microstructure and mechanical function.
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