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Bone mechanical functionalization by control of bone quality using stress field

Research Project

Project/Area Number 25420755
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Ishimoto Takuya  大阪大学, 工学(系)研究科(研究院), 講師 (50508835)

Co-Investigator(Renkei-kenkyūsha) NAKANO Takayoshi  大阪大学, 大学院工学研究科, 教授 (30243182)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨配向性 / 骨質 / 応力場 / 人為的応力負荷 / オステオサイト / メカノバイオロジー / 力学機能 / 配向性 / OCY / 人為的力学負荷 / 人為的負荷 / 骨配向化 / 配向化機構 / 骨力学機能 / 配向化 / 機能適応
Outline of Final Research Achievements

Artificial and quantitative load was applied onto the rat long bone utilizing micro-material testing machine and bone's adaptive responses were analyzed. The preferential orientation of apatite which we focusing on as a bone quality parameter changed depending on the magnitude of the applied load, which represents the success in optimizing the bone mechanical function by applying artificial load through the change of bone quality. In the present study, we achieved substantial results from both clinical (controlling bone mechanical function utilizing an external field) and scientific (clarifying new aspect of bone's adaptive response which had previously only been examined with regard to bone mass) aspects.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results)

  • [Journal Article] Analysis of Osteocyte Morphology in terms of Sensation of In Vivo Stress Applied on Bone2014

    • Author(s)
      T. Ishimoto, K. Kawahara, A. Matsugaki, J. Wang, H. Kamioka and T. Nakano
    • Journal Title

      Materials Science Forum

      Volume: 783-786 Pages: 1265-1268

    • DOI

      10.4028/www.scientific.net/msf.783-786.1265

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preferential Orientation of Collagen/Biological Apatite in Growing Rat Ulna under an Artificial Loading Condition2013

    • Author(s)
      J. Wang, T. Ishimoto, T. Nakano
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 54 Issue: 8 Pages: 1257-1261

    • DOI

      10.2320/matertrans.ME201314

    • NAID

      10031189471

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Change in preferential alignment of bone apatite in response to artificially altered principal strain in regenerated rat ulna2016

    • Author(s)
      T. Ishimoto, A. Murakami, T. Nakano
    • Organizer
      9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM9)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2016-08-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨への強制的荷重負荷が骨形態・配向化に与える影響2016

    • Author(s)
      石本卓也, 門田耕平, 中野貴由
    • Organizer
      第36回日本骨形態計測学会
    • Place of Presentation
      朱鷺メッセ, 新潟
    • Year and Date
      2016-06-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Apatite orientation and material property of bone are enhanced by artificially elevated load2016

    • Author(s)
      T. Ishimoto, J. Wang, K. Kadota, T.W. Kim, T. Nakano
    • Organizer
      International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’2011)
    • Place of Presentation
      Graz Convention Center - MESSE GRAZ, Graz, Austria
    • Year and Date
      2016-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bone formation with preferentially oriented extra cellular matrix under mandatorily applied loading2015

    • Author(s)
      T. Ishimoto, J. Wang, T. Nakano
    • Organizer
      The Twenty-Fourth International Symposium on Processing and Fabrication of Advanced Materials (PFAM XXIV)
    • Place of Presentation
      Kansai University Senriyama Campus Centenary Memorial Hall, Suita
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of artificial loading on biological apatite (BAp) orientation in regenerated rat ulna2015

    • Author(s)
      A. Murakami, T. Ishimoto, T. Nakano
    • Organizer
      The Twenty-Fourth International Symposium on Processing and Fabrication of Advanced Materials (PFAM XXIV)
    • Place of Presentation
      Kansai University Senriyama Campus Centenary Memorial Hall, Suita
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オステオサイトの応力感受機能に基づく骨配向化挙動2015

    • Author(s)
      村上愛実, 石本卓也, 中野貴由
    • Organizer
      第7回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ, 京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] アパタイト配向化構造は骨の力学機能を支配する2015

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル, 東京
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 卵巣摘出ラット尺骨への強制応力負荷によるアパタイト配向化2015

    • Author(s)
      石本卓也, Kim TeaWan, 藤谷渉, 中野貴由
    • Organizer
      日本金属学会2015年春期(第156回)大会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 骨配向化ならびに力学機能との相関2014

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      第22回顎顔面バイオメカニクス学会大会
    • Place of Presentation
      (株)UKデンタル長崎店
    • Year and Date
      2014-11-22 – 2014-11-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ラット尺骨への強制的応力負荷に対する骨量・骨密度・配向性変化2014

    • Author(s)
      石本卓也, 王俊, 中野貴由
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット尺骨への人為的in vivo負荷に対する骨配向化応答2014

    • Author(s)
      石本卓也, 王俊, 藤谷渉, 中野貴由
    • Organizer
      日本金属学会2014年秋期(第155回)大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット長管骨再生部の骨配向化に対する人為的応力負荷の影響2014

    • Author(s)
      村上愛実, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2014年秋期(第155回)大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット尺骨への人為的荷重負荷による骨配向化2014

    • Author(s)
      石本卓也, 王俊, 中野貴由
    • Organizer
      第34回日本骨形態計測学会
    • Place of Presentation
      さっぽろ芸文館
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Presentation] Effect of strain magnitude on biological apatite orientation and mechanical functions in rat ulna2014

    • Author(s)
      J. Wang, T. Ishimoto, T. Nakano
    • Organizer
      日本金属学会2014年春期(第153回)大会
    • Place of Presentation
      東京工業大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 応力感受に注目したオステオサイトの異方性形態と骨配向性2013

    • Author(s)
      石本卓也, 王俊, 川原啓太, 中野貴由
    • Organizer
      日本金属学会2013年秋期(第152回)大会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of osteocyte morphology in terms of sensation of in vivo stress applied on bone2013

    • Author(s)
      T. Ishimoto, K. Kawahara, J. Wang、H. Kamioka and T. Nakano
    • Organizer
      Termec2013
    • Place of Presentation
      Rio Hotel (Las Vegas)
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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