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Development of regenerative medicine techniques by control of collagen fiber orientation and application of new materials

Research Project

Project/Area Number 25420761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionTokai University

Principal Investigator

Kuzumaki Toru  東海大学, 工学部, 教授 (50396909)

Co-Investigator(Kenkyū-buntansha) TRIGOE KOHJUN  東海大学, 医学部, 教授 (50126603)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords生体材料 / 再生医療 / コラーゲン線維 / 人工腱 / 人工靭帯 / リガメントゲル / 材料工学 / 新素材応用 / 配向組織 / 新素材開発 / アキレス腱 / カーボンナノチューブ / 紡績糸 / 熱処理 / コラーゲン線維 / 張力印加 / 組織制御
Outline of Final Research Achievements

Tendon gel secreted from a parent tendon is regenerated by applying the tension. However, the detailed condition of tensile stimulus to promote regeneration of tendon gel has never been clarified yet. In this study, evaluations of an appropriate tensile mode and of the optimum timing of applying the tension to tendon gel were conducted by tensile tests and structural analyses. An infrared spectroscopy revealed that characteristic peaks that appeared in tendon gel on day 3 and day 5 disappeared in tendon gel on day 10. Disappearance of the peaks means maturity of tendon gel and it show us the optimum timing that the tension should be applied to tendon gel. The effect of tensile load on tendon gel preserved for 10 days was investigated by various tensile tests. In normal tensile test, tendon gel was elongated into a thin cord of collagen fibres, and the maximum diameter of a collagen fibre was approximately 45 times large than that of the normal Achilles tendon of mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Fourier transform infrared spectroscopy and atomic force microscopy observations of regenerative tendon biomaterial2015

    • Author(s)
      K. Yamazaki, K. Suzuki. K. Torigoe, T. Kuzumaki
    • Journal Title

      Proc. of the 120th Annual Meeting of the Japanese Association of Anatomists and the 92th Annual Meeting of the Physiological Society of Japan, The Journal of Physiological Sciences

      Volume: 65

    • Related Report
      2014 Research-status Report
  • [Journal Article] Tensile test and atomic force microscopic analysis on regenerative tendon biomaterial2013

    • Author(s)
      K. Yamazaki, R. Sato, D. Morita, K. Torigoe and T. Kuzummaki
    • Journal Title

      Proc. of the MJIIT-JUC Joint International Symposium 2013

      Volume: 1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 生体分泌組織リガメントゲルを用いた人工靭帯の開発2016

    • Author(s)
      鈴木慶一、佐藤 匠、青柳晃司、鳥越甲順、葛巻 徹
    • Organizer
      第15回再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市・北区)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fourier transform infrared spectroscopy and atomic force microscopy observations of regenerative tendon biomaterial2015

    • Author(s)
      K.Yamazaki, K. Suzuki, K. Torigoe, T. Kuzumaki
    • Organizer
      The 120th Annual Meeting of the Japanese Association of Anatomists and the 92th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場(神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 原子間力顕微鏡と顕微赤外分光法による再生腱形成の初期過程の解析2015

    • Author(s)
      山﨑勝史、鈴木慶一、鳥越甲順、葛巻徹
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 通電加熱したカーボンナノチューブ紡績糸の機械的性質と構造の評価2014

    • Author(s)
      中込和輝、佐藤匡、飯島徹、稲垣裕大、林靖彦、葛巻徹
    • Organizer
      第28回ダイヤモンドシンポジウム
    • Place of Presentation
      東京電機大学(東京都)
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 通電加熱したカーボンナノチューブ紡績糸の機械的性質の評価2014

    • Author(s)
      中込和輝、佐藤匡、飯島徹、稲垣裕大、林靖彦、葛巻徹
    • Organizer
      第75回応用物理学会秋季学術講演会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 原子間力顕微鏡と顕微赤外分光による再生腱・膠原線維の配向機構の解析

    • Author(s)
      山﨑勝史、森田大貴、鳥越甲順、葛巻 徹
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] リガメントゲルの産生方法および人工靭帯の作製方法2015

    • Inventor(s)
      葛巻 徹、    鳥越甲順
    • Industrial Property Rights Holder
      東海大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-185442
    • Filing Date
      2015-09-18
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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