| Project/Area Number |
25420767
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural/Functional materials
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| Research Institution | Japan Fine Ceramics Center |
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Principal Investigator |
Hashimoto Masami 一般財団法人ファインセラミックスセンター, その他部局等, 研究員 (20450851)
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| Co-Investigator(Kenkyū-buntansha) |
KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授 (50292222)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 酸化チタン粒子 / 水酸化アパタイト / 擬似体液 / 酸窒化 / バイオマテリアル / 酸化チタン / 骨セメント / 生体活性 / アパタイト / 細胞 |
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| Outline of Final Research Achievements |
TiO2 particles that were formed by heat treatment in a nitrogen atmosphere with an extremely low oxygen partial pressure exhibited high hydroxyapatite (HAp)-forming ability in simulated body fluid (SBF). X-ray diffraction (XRD), and scanning transmission electron microscopy (STEM) combined with electron energy loss spectroscopy (EELS) indicated that the particles were rutile-type TiO2, which scarcely contains nitrogen. Electron spin resonance (ESR) spectra revealed the reduction of Ti4+ in TiO2 to Ti3+ and the simultaneous introduction of oxygen vacancies to maintain charge neutrality. The enhanced HAp-forming ability of the TiO2 particles was likely related to their negatively charged surface, induced by water adsorption on oxygen vacancies, which resulted in acidic point formation. The compressive strength of PMMA-TiO2 bone cement was higher than that of commercial cement. Therefore, PMMA-TiO2 bone cement is considered to be useful for bone-reparing material.
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