| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Titanium peroxide nanoparticles (TiOxNPs) was synthesized and their efficacy as novel agents that can potently enhance the effects of radiation in the treatment of pancreatic cancer was investigated. The core structures of the PAA-TiOxNPs were found to be of the anatase type. The TiOxNPs and PAA-TiOxNPs showed a distinct ability to produce hydroxyl radicals in response to X-ray irradiation in a dose- and concentration-dependent manner, whereas the TiO2NPs did not. The combination of the PAATiOxNPs and X-ray irradiation induced significantly stronger tumor growth inhibition compared to treatment with either PAA-TiOxNPs or X-ray alone. In addition, bio-distribution of PAATiOx in Xenograft mouse model was identified, and the evaluation method of effect of X-ray irradiation on cell line was also established. Together these findings, TiOxNPs are potential agents for enhancing the effects of radiation on pancreatic cancer via hydroxyl radical production.
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