| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Here, we attempted to develop egg-based oral immunotherapy using genetically manipulated (GM) chickens. By using egg white derived from GM hens producing human T-cell epitopes fused with MHC molecules (MHC-Crp-Fc), the number of sneezing and IgE level were significantly decreased in allergic mice fed with MHC-Crp-Fc-containing egg white. TGF-beta1 could be produced in an oviduct-specific manner. Recombinant RANKL that can induce M cells was produced. Eggs derived from GM chickens may be served as edible pharmaceuticals for allergy immunotherapy.
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