| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, we used a bacterial expression system to produce a bispecific antibody that was heterotetramerized through hetero-associating peptides and that targeted cancer cells. As the results, we succeeded in preparing the recombinant antibody which bound to two target molecules simultaneously. Furthermore, the bispecific antibody showed cytotoxic activity against target tumor cells, and its cytotoxicity was comparable to that of a commercial therapeutic antibody. These results show that our method has high potential for the cost-efficient production of highly functional antibodies.
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