| Project/Area Number |
25420839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | solute permeability / peritoneal tissue / cell sheets / cell sheet lamination / kidney failure / 腹膜透析 / 積層化細胞シート / 溶質透過係数 / 腹膜組織モデル / 再生治療 / 組織工学 / 化学工学 / 再生医療 |
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| Outline of Final Research Achievements |
This study is one of the development of techniques to assess whether PD liquid used in renal failure treatment is suitable for the living body. By stacking the cell sheet in vitro, it was successful in the production of pseudo-peritoneal tissue composed of three layers. Further, the pseudo-peritoneal tissue lumen structure of a single layer was observed vessels were observed. On the other hand, the solute permeability coefficient of the pseudo-peritoneal tissue, compared to a single-layer structure, 1 / 26.5 in molecular weight of 4000, 1 / 4.5 in molecular weight of 10,000, 1 / 1.9 in molecular weight of 70000, the solute is less likely to pass by organizing It becomes and it is shown that, became a result close to a living body.
To create a pseudo-peritoneal tissue in vitro, it has succeeded in the development of the evaluation method.
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