Inhibitory effects of hybrid liposomes toward cancer metastasis

• Project/Area Number: 25420843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Sojo University
• Principal Investigator: ICHIHARA Hideaki 崇城大学, 生物生命学部, 准教授 (70369114)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Yoko 崇城大学, 生物生命学部, 教授 (00133562) ; UEOKA Ryuichi 崇城大学, 生物生命学部, 客員研究員 (70099076)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 癌 / 転移 / シグナル伝達 / ナノメディシン / in vivo

Outline of Final Research Achievements

We examined the therapeutic effects of hybrid liposomes (HL) composed of L-alpha-dimyristylphosphatidylcholine (DMPC) and polyoxyethylene (25) dodecyl ether (C12(EO)25) on the growth of human colorectal cancer (WiDr) cells in vitro and in vivo. The inhibitory effects of HL on the growth of WiDr cells along with apoptosis were obtained in vitro. Remarkable inhibitory effects of HL for the liver metastasis of colorectal cancer cells along with apoptosis were revealed on the basis of histological analysis. Prolonged survival was obtained for the xenograft mouse models of colorectal cancer after the treatment with HL in vivo.

Research Products

• [Journal Article] Therapeutic effects of trehalose liposomes against lymphoblastic leukemia leading to apoptosis in vitro and in vivo (2016)
  • Author(s): Yoko Matsumoto, Keiji Kuwabara, Hideaki Ichihara, Masataka Kuwano
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 26 Issue: 2 Pages: 301-305
  • DOI: 10.1016/j.bmcl.2015.12.025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic effects of hybrid liposomes with downregulation of inflammatory cytokine for model mice of rheumatoid arthritis in vivo (2015)
  • Author(s): Hideaki Ichihara, Shuichi Yamasaki, Motoki Hino, Yoko Matsumoto, Ryuichi Ueoka
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 25 Issue: 13 Pages: 2686-2689
  • DOI: 10.1016/j.bmcl.2015.04.083
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibitory effects of hybrid liposomes on the growth of non-small cell lung carcinoma cells and anti-invasive activity by ceramide generation without any drugs (2015)
  • Author(s): Hideaki Ichihara, Yuji Komizu, Ryuichi Ueoka, Yoko Matsumoto
  • Journal Title: Journal of Carcinogenesis & Mutagenesis Volume: 6 Issue: 04
  • DOI: 10.4172/2157-2518.1000230
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hybrid liposomes inhibit the growth and angiogenesis in human breast cancer model (2015)
  • Author(s): Hideaki Ichihara, Shuichi Yamasaki, Motoki Hino, Ryuichi Ueoka, Yoko Matsumoto
  • Journal Title: Journal of Carcinogenesis & Mutagenesis Volume: 6 Issue: 01
  • DOI: 10.4172/2157-2518.1000207
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic effects of hybrid liposomes with downregulation of inflammatory cytokine for model mice of rheumatoid arthritis in vivo (2015)
  • Author(s): HideakiIchihara, Shuichi Yamasaki, Motoki Hino, Ryuichi Ueoka, Yoko Matsumoto
  • Journal Title: Bioorganic Medicinal Chemistry Letters Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of HIV-1 entry by the tricyclic coumarin GUT-70 through the modification of membrane fluidity. (2015)
  • Author(s): Matsuda K, Hattori S, Kariya R, Komizu Y, Kudo E, Goto H, Taura M, Ueoka R, Kimura S, Okada S.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 457(3) Issue: 3 Pages: 288-94
  • DOI: 10.1016/j.bbrc.2014.12.102
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis (2014)
  • Author(s): Yoko Matsumoto, Hideaki Ichihara, Motoki Hino, Masayo Umebayashi, Ryuichi Ueoka
  • Journal Title: Drug Delivery Volume: 21 Issue: 5 Pages: 619-626
  • DOI: 10.3109/10717544.2013.869635
  • Peer Reviewed / Open Access
• [Journal Article] Cell cycle arrest by hybrid liposomes for human lung carcinoma cells (2014)
  • Author(s): Y. Komizu, M. Yukihara, Y. Matsumoto, R. Ueoka
  • Journal Title: J. Carcinog. Mutagen Volume: 5 Issue: 01
  • DOI: 10.4172/2157-2518.1000157
  • Peer Reviewed / Open Access
• [Journal Article] Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity (2014)
  • Author(s): K. Matsuda, S. Hattori, Y. Komizu, R. Kariya, R. Ueoka, S. Okada
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 24 Issue: 9 Pages: 2115-2117
  • DOI: 10.1016/j.bmcl.2014.03.041
  • Peer Reviewed / Open Access
• [Journal Article] Nanotherapy with hybrid liposomes for colorectal cancer along with apoptosis in vitro and in vivo (2014)
  • Author(s): HideakiIchihara, Shinichiro Nakagawa, Yusuke Matsuoka, Kenshi Yoshida, Yoko Matsumoto, Ryuichi Ueoka
  • Journal Title: Anticancer Research Volume: 34 Pages: 4701-4708
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hybrid nanoparticles inhibit growth of human prostate cancer cells by induction of apoptosis (2014)
  • Author(s): Yuji Komizu, Toshiko Ueoka, Mamiko Yukihara, Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
  • Journal Title: SOJ Pharmacy & Pharmaceutical Science Volume: 1 Pages: 1-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic Effects of Cationic Hybrid Liposomes on the Hepatic Metastasis of Colon Carcinoma Along with Apoptosis <i>in Vivo</i> (2014)
  • Author(s): H. Ichihara, M. Hino, R. Ueoka, Y. Matsumoto
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 37 Issue: 3 Pages: 498-503
  • DOI: 10.1248/bpb.b13-00764
  • NAID: 130003390947
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] ハイブリッドリポソームによるがん治療と分子メカニズム (2014)
  • Author(s): 上岡龍一, 市原英明, 古水雄志
  • Journal Title: 生物物理 Volume: 54 Pages: 5-10
  • NAID: 130003391392
• [Journal Article] Therapeutic Effects of Autologous Lymphocytes Activated with Trastuzumab for Xenograft Mouse Models of Human Breast Cancer (2013)
  • Author(s): S. Nakagawa, Y. Matsuoka, H. Ichihara, H. Yoshida, K. Yoshida, R. Ueoka
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Issue: 5 Pages: 861-865
  • DOI: 10.1248/bpb.b12-01084
  • NAID: 130003361416
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Immunostimulatory Effects of Extract from <i>Nori</i> (<i>Porphyra yezoensis</i>) <i>in Vitro</i> and <i>in Vivo</i> (2013)
  • Author(s): 北島 英樹, 古水 雄志, 市原 英明, 後藤 浩一, 土井 孝史, 稲野 達郎, 上岡 龍一
  • Journal Title: KAGAKU KOGAKU RONBUNSHU Volume: 39 Issue: 4 Pages: 359-362
  • DOI: 10.1252/kakoronbunshu.39.359
  • NAID: 10031188074
  • ISSN: 0386-216X, 1349-9203
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells (2013)
  • Author(s): H. Kitajima, Y. Komizu, H. Ichihara, K. Goto, R. Ueoka
  • Journal Title: Cancer Med Volume: (in press) Issue: 3 Pages: 267-278
  • DOI: 10.1002/cam4.67
  • Peer Reviewed
• [Presentation] Therapeutic effects of hybrid liposome against human carcinoma using model mice of carcinoma (2015)
  • Author(s): Kuwabara Keiji, Hideaki Ichihara, Yoko Matsumoto
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Inhibitory effects of liposomes including trehalose surfactants on the growth of tumor cells along with apoptosis (2015)
  • Author(s): Kuwano Masataka, Hideaki Ichihara, Yoko Matsumoto
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Therapeutic effects of hybrid liposomes against colon carcinoma using xenograft mouse models of colon carcinoma (2015)
  • Author(s): Okumura Masaki, Hideaki Ichihara, Yoko Matsumoto
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Chemotherapy with hybrid liposomes without drugs along with induction of apoptosis in vivo (2015)
  • Author(s): Hideaki Ichihara, Yoko Matsumoto
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Anti-tumor effects of cationic hybrid liposomes against colon carcinoma along with apoptosis in vitro and in vivo (2015)
  • Author(s): Yoko Matsumoto, Motoki Hino, Hideaki Ichihara
  • Organizer: The 74nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場（愛知県 名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Therapeutic effects of hybrid liposomes with anti-angiogenic/metastatic activity for breast tumors (2015)
  • Author(s): Yoko Matsumoto, Hideaki Ichihara
  • Organizer: The 74nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場（愛知県 名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] トレハロースリポソームの腫瘍細胞認に対するアポトーシス誘導による制がん効果 (2015)
  • Author(s): 桑原啓司, 桑野将好, 市原英明, 松本陽子
  • Organizer: 日本化学会九州支部設立100周年記念国際シンポジウム、第５２回化学 関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（北九州市小倉北区浅野）
  • Year and Date: 2015-06-27 – 2015-06-28
• [Presentation] 担がんマウスを用いたハイブリッドリポソームの大腸がんに対する治療効果 (2015)
  • Author(s): 奥村真樹,市原英明,松本陽子
  • Organizer: 日本化学会九州支部設立100周年記念国際シンポジウム、第５２回化学 関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（北九州市小倉北区浅野）
  • Year and Date: 2015-06-27 – 2015-06-28
• [Presentation] リウマチモデルマウスに対するハイブリッドリポソームの治療効果 (2015)
  • Author(s): 山﨑周一, 髙木麻里, 市原英明, 松本陽子
  • Organizer: 日本化学会九州支部設立100周年記念国際シンポジウム、第５２回化学 関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（北九州市小倉北区浅野）
  • Year and Date: 2015-06-27 – 2015-06-28
• [Presentation] ハイブリッドリポソームの転移抑制によるがん治療効果 (2015)
  • Author(s): 中島裕美, 菊本ありさ, 市原英明, 松本陽子
  • Organizer: 日本化学会九州支部設立100周年記念国際シンポジウム、第５２回化学 関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（北九州市小倉北区浅野）
  • Year and Date: 2015-06-27 – 2015-06-28
• [Presentation] Remarkable therapeutic effects of hybrid liposomes for model mice of carcinoma along with apoptosis (2015)
  • Author(s): Hideaki Ichihara, Yoko Matsumoto
  • Organizer: 日本化学会九州支部設立100周年記念国際シンポジウム、第５２回化学 関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（北九州市小倉北区浅野）
  • Year and Date: 2015-06-27 – 2015-06-28
• [Presentation] トレハロースリポソームの腫瘍細胞に対するアポトーシス誘導による制がん効果 (2015)
  • Author(s): 桑原 啓司, 桑野 将好, 市原 英明, 松本 陽子
  • Organizer: 第52回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（福岡県 北九州市）
  • Year and Date: 2015-06-27
• [Presentation] 担がんマウスを用いたハイブリッドリポソームの大腸がんに対する治療効果 (2015)
  • Author(s): 奥村 真樹, 市原 英明, 松本 陽子
  • Organizer: 第52回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（福岡県 北九州市）
  • Year and Date: 2015-06-27
• [Presentation] リウマチモデルマウスに対するハイブリッドリポソームの治療効果 (2015)
  • Author(s): 山﨑 周一, 髙木 麻里, 市原 英明, 松本 陽子
  • Organizer: 第52回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（福岡県 北九州市）
  • Year and Date: 2015-06-27
• [Presentation] ハイブリッドリポソームの転移抑制によるがん治療効果 (2015)
  • Author(s): 中島 裕美, 菊本 ありさ, 市原 英明, 松本 陽子
  • Organizer: 第52回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（福岡県 北九州市）
  • Year and Date: 2015-06-27
• [Presentation] Remarkable therapeutic effects of hybrid liposomes for model mice of carcinoma along with apoptosis (2015)
  • Author(s): Hideaki Ichihara, Yoko Matsumoto
  • Organizer: 第52回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場（福岡県 北九州市）
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] 肺がん細胞におけるハイブリッドリポソームによるセラミド産生及び浸潤抑制 (2015)
  • Author(s): 市原英明、松本陽子
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 松山全日空ホテル（愛媛県松山市一番町）
  • Year and Date: 2015-06-10 – 2015-06-12
• [Presentation] 肺がん細胞におけるハイブリッドリポソームによるセラミド産生及び浸潤抑制 (2015)
  • Author(s): 市原 英明, 松本 弓美, 松本 陽子
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 松山全日空ホテル（愛媛県 松山市）
  • Year and Date: 2015-06-10
• [Presentation] リポソームを用いた副作用のないが認ん治療を目指した展開 (2015)
  • Author(s): 松本陽子
  • Organizer: 化学工学会第80年会
  • Place of Presentation: 芝浦工業大学豊洲キャンパス（東京都江東区豊洲）
  • Year and Date: 2015-03-19 – 2015-03-21
  • Invited
• [Presentation] トレハロースリポソー ムによるリンパ腫細胞膜の脂質ラフトのクラスター形成 (2015)
  • Author(s): 桑野将好, 市原英明, 松本陽子
  • Organizer: 化学工学会第80年会
  • Place of Presentation: 芝浦工業大学豊洲キャンパス（東京都江東区豊洲）
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] カチオン性脂質含有ハイブリッドリポソームの大腸がんに対する治療効果 (2015)
  • Author(s): 元村宗誠, 市原英明, 松本陽子
  • Organizer: 化学工学会第80年会
  • Place of Presentation: 芝浦工業大学豊洲キャンパス（東京都江東区豊洲）
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] 疾患細胞膜を標的とするリポソームによるがん治療 (2015)
  • Author(s): 松本陽子
  • Organizer: 国際高等研究所「分子基盤に基づく生体機能への揺らぎとダイナミックネットワークの解明」研究会
  • Place of Presentation: 国際高等研究所（京都府木津川市木津川台）
  • Year and Date: 2015-03-17 – 2015-03-18
  • Invited
• [Presentation] Nobel liposomes composed of phosphatidylcholine and trehalose surfantants inhibit the growth of tumor cells along with apoptosis (2014)
  • Author(s): Yoko Matsumoto
  • Organizer: 8th International Symposium on Nanomedicine
  • Place of Presentation: Ehime University,Nanka Memorial Hall（Matsuyama, Ehime）
  • Year and Date: 2014-12-04 – 2014-12-06
  • Invited
• [Presentation] Hybrid liposomes inhibit the growth of human lung cancer cells by cell-cycle regulation (2014)
  • Author(s): Yumi Matsumoto,Yuji Komizu,Hideaki Ichihara,Yoko Matsumoto
  • Organizer: 8th International Symposium on Nanomedicine
  • Place of Presentation: Ehime University,Nanka Memorial Hall（Matsuyama, Ehime）
  • Year and Date: 2014-12-04 – 2014-12-06
• [Presentation] Therapeutic effects of cationic liposomes on the hepatic metastasis of colon carcinoma in vivo (2014)
  • Author(s): Hideaki Ichihara, Motoki Hino, Yoko Matsumoto
  • Organizer: 8th International Symposium on Nanomedicine
  • Place of Presentation: Ehime University,Nanka Memorial Hall（Matsuyama, Ehime）
  • Year and Date: 2014-12-04 – 2014-12-06
• [Presentation] Nanotherapy with empty liposomes for carcinoma (2014)
  • Author(s): Yoko Matsumoto
  • Organizer: The 9th International Conference of Anticancer Research
  • Place of Presentation: Halkidiki,Greece
  • Year and Date: 2014-10-06 – 2014-10-10
  • Invited
• [Presentation] Therapeutic Effects of Hybrid Liposomes with Anti-angiogenic Activity for Breast Tumors (2014)
  • Author(s): HideakiIchihara, Motoki Hino, Ryuichi Ueoka, Yoko Matsumoto
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市西区みなとみらい）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 出熱力学量測定によるハイブリッドリポソームの揺らぎ検出 (2014)
  • Author(s): 中曽根祐介、古水雄志、松本陽子、松下琢、上岡龍一、寺嶋正秀
  • Organizer: 第8回分子科学討論会
  • Place of Presentation: 広島大学東広島キャンパス（広島県東広島市鏡山）
  • Year and Date: 2014-09-21 – 2014-09-24
• [Presentation] ハイブリッドリポソームの血管新生抑制活性による乳がん治療効果 (2014)
  • Author(s): 菊本ありさ, 市原英明, 松本陽子
  • Organizer: 化学工学会第46回秋季大会
  • Place of Presentation: 九州大学伊都キャンパス（福岡県福岡市西区元岡）
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] トレハロース含有リポソームのリンパ腫瘍に対する制がん効果 (2014)
  • Author(s): 桑野将好, 市原英明, 松本陽子
  • Organizer: 化学工学会第46回秋季大会
  • Place of Presentation: 九州大学伊都キャンパス（福岡県福岡市西区元岡）
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] 大腸がんに対するカチオン性脂質認含有ハイブリッドリポソームの治療効果 (2014)
  • Author(s): 元村宗誠, 市原英明, 松本陽子
  • Organizer: 化学工学会第46回秋季大会
  • Place of Presentation: 九州大学伊都キャンパス（福岡県福岡市西区元岡）
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] Chemotherapy and detection of cancer using hybrid liposomes (2014)
  • Author(s): HideakiIchihara, YokoMatsumoto, RyuichiUeoka
  • Organizer: 9th International Forum on Multimedia and Image Processing (IFMIP) 2014 (World Automation Congress; WAC)
  • Place of Presentation: Hawaii（USA）
  • Year and Date: 2014-08-03 – 2014-08-07
  • Invited
• [Presentation] ハイブリッドリポソームの血管新生抑制活性による乳がん治療効果 (2014)
  • Author(s): 市原英明, 日野元貴, 松本陽子, 上岡龍一
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 仙台市情報・産業プラザ（宮城県仙台市青葉区中央）
  • Year and Date: 2014-06-25 – 2014-06-27
• [Presentation] ハイブリッドリポソームを用いた形質転換肝幹細胞の選択的排用除 (2014)
  • Author(s): 稲村恒亮, 石井貴晃, 押方歩, 古水雄志, 上岡龍一, 松下琢
  • Organizer: 日本組織培養学会第87回大会
  • Place of Presentation: 星陵会館（東京都千代田区永田町）
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 大腸がんに対するカチオン性脂質含有ハイブリットリポソームの制がん効果 (2013)
  • Author(s): 日野元貴, 市原英明, 松本陽子
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
• [Presentation] Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis (2013)
  • Author(s): Motoki Hino, Hideaki Ichihara, Yoko Matsumoto
  • Organizer: The 3rd Sojo-UTP Joint Seminar on Nano & Bio
  • Place of Presentation: 崇城大学（熊本市西区）
• [Presentation] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vitro and in vivo (2013)
  • Author(s): Yuji Komizu, Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（横浜市西区）
• [Presentation] Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo (2013)
  • Author(s): Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（横浜市西区）
• [Presentation] Immunostimulation effects of extract from nori (Porphyra yezoensis) in vitro and in vivo (2013)
  • Author(s): Koichi Goto, Hideki Kitajima, Yuji Komizu, Hideaki Ichihara, Takashi Doi, Tatsuro Inano, Ryuichi Ueoka
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（横浜市西区）
• [Book] Membrane-Targeted Nanotherapy with Hybrid Liposomes for Cancer Cells Leading to Apoptosis, Molecular Science of Fluctuations Toward Biological Functions (2016)
  • Author(s): Ryuichi Ueoka, Yoko Matsumoto, Hideaki Ichihara, Yuji Komizu
  • Total Pages: 23
  • Publisher: Springer
• [Remarks] 崇城大学生物生命学部応用生命科学科医用生体工学講座松本研究室
  • URL: http://www.life.sojo-u.ac.jp/biomed/matsumoto/
• [Remarks] 崇城大学生物生命学部応用生命科学科医用生体工学講座
  • URL: http://www.life.sojo-u.ac.jp/biomed/index.html