Production of 99Mo/99mTc generator using 99Mo recoil out from molybdenum nanoparticles target by the 100Mo(n,2n)99Mo reaction

• Project/Area Number: 25420913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nuclear engineering
• Research Institution: National Institutes for Quantum and Radiological Science and Technology (2016); Japan Atomic Energy Agency (2013-2015)
• Principal Investigator: Hatsukawa Yuichi 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (40343917)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Mo/Tcジェネレータ / Mo-99 / Tc-99m / (n,2n)反応 / 反跳核種 / 加速器中性子 / Mo-99/Tc-99mミルカー / 医療用RI / （n,2n）反応 / ジェネレータ / 反跳エネルギー / ナノ粒子ターゲット / 99Mo/99mTc / ジェネレーター / ナノ粒子 / 加速器中性子核反応 / 反跳作用 / 高比放射能 / 金属ナノ粒子 / Mo-99/Tc-99mジェネレータ / 反跳反応

Outline of Final Research Achievements

We propose a 99Mo production project via the 100Mo(n,2n)99Mo reaction using fast neutrons (E>10MeV) from accelerator. Only low specific radioactive 99Mo, however, can be obtained in this method. Although labeled technetium compounds would be available by this method, a compact technetium generator is still required in medical facilities. The purpose of this study is to investigate about production of high specific radioactivity of 99Mo and 99Mo/99mTc compact generator using and the 100Mo(n,2n)99Mo reaction with nanoparticle molybdenum target. In the fast neutron reaction with nanoparticle molybdenum targets, a certain amount of 99Mo ions are expected to be recoiled out from the target and isolated.

Research Products

• [Journal Article] Production of 95mTc for Compton camera imaging (2015)
  • Author(s): Y. Hatsukawa, K. Hashimoto, K. Tsukada, T. Sato, M. Asai, A. Toyoshima, Y. Nagai, T. Tanimori, S. Sonoda, S. Kabuki, H. Saji. H. Kimura
  • Journal Title: J. Radioanal Nucl. Chem. Volume: 303 Issue: 2 Pages: 1283-1285
  • DOI: 10.1007/s10967-014-3508-0
  • Peer Reviewed
• [Presentation] PRODUCTION OF TECHNETIUM ISOTOPES FOR COMPTON CAMERA IMAGIMG (2017)
  • Author(s): Y. Hatsukawa, K. Tsukada, K. Hashimoto, T. Sato, M. Asai, A. Toyoshima, Y. Nagai, T. Tanimori, S. Sonoda, S. Kabuki, H. Kimura, A. Takada, T. Mizumoto, T. Hayakawa,
  • Organizer: The 62nd Annual Radiobioassay & Radiochemical Measurements Conference
  • Place of Presentation: Honolulu, HI USA
  • Year and Date: 2017-02-06
  • Int'l Joint Research
• [Presentation] コンプトンカメライメージング用Tc-95m及びTc-96の生成研究 (2016)
  • Author(s): 初川雄一、塚田和明、橋本和幸、佐藤哲也、浅井雅人、豊島厚史、永井泰樹、谷森達、園田信也、株木重人、木村寛之、高田淳史、水本哲也、早川岳人
  • Organizer: 日本放射化学会
  • Place of Presentation: 新潟大学、新潟市
  • Year and Date: 2016-09-09
• [Presentation] Improvement in production yeild of 85Sr@C60 using nuclear recoil (2015)
  • Author(s): Y. Miyashita, K. Akiyama, Y. Hatsukawa, S. Kubuki
  • Organizer: The 2015 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2105)
  • Place of Presentation: Honolulu, HI, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Production of 95mTc for Compton Camera imaging (2015)
  • Author(s): Y. Hatsukawa, K. Tsukada, K. Hashimoto, T. Sato, M. Asai, A. Toyoshima, Y. Nagai, T. Tanimori, S. Sonoda, S. Kabuki, H. Kimura
  • Organizer: The 2015 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2105)
  • Place of Presentation: Honolulu, HI, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Production of 99Mo/99mTc generator using high specific activity of 99Mo recoil out from molybdenum nanoparticles target by the 100Mo(n,2n)99Mo reaction (2015)
  • Author(s): Y. Hatsukawa,K. Tsukada, K. Hashimoto, T. Sato, M. Asai, and A. Toyoshima
  • Organizer: NAMLS-11
  • Place of Presentation: Delft, Netherland
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] Production of 99Mo/99mTc generator using high specific activity of 99Mo recoiling out from molybdenum nano-parcticles target by the 100Mo(n,2n)99Mo reaction (2014)
  • Author(s): Y. Hatsukawa
  • Organizer: INCC
  • Place of Presentation: サンパウロ、ブラジル
  • Year and Date: 2014-09-23
• [Presentation] Production of 99Mo/99mTc generator using Szilard-Chalmers reaction (2014)
  • Author(s): Y. Hatsukawa, K. Tsukada, K. Hashimoto,T. Sato, M. Asai, and A. Toyoshima
  • Organizer: RadChem2014, 17th Radiochemical Conference
  • Place of Presentation: Marianske Lazne、チェコ共和国
  • Year and Date: 2014-05-11 – 2014-05-16