Searching for fru-target genes that regulate the development of sexual dimorphisms in Drosophila central neurons.
Project/Area Number |
25430001
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Tohoku University |
Principal Investigator |
Ito Hiroki 東北大学, 生命科学研究科, 研究支援者 (00425612)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 脳 / ニューロン / 性的二型 / 求愛 / 神経回路 / 軸索投射 / 性決定 / ショウジョウバエ / 求愛行動 / キイロショウジョウバエ / クロマチン / fruitless / robo1 |
Outline of Final Research Achievements |
The Drosophila fruitless (fru) gene is regarded as a master regulator of the formation of male courtship circuitry, yet little is known about its molecular basis of action. Fru proteins are expressed in a small population (~2%) of neurons of the brains in males, but not females. In this study, we showed the following: (1) Fru binds to the promoter of robo1, an axon guidance-regulating gene, and represses the expression of robo1, (2) Robo1 suppresses formation of the male-specific neurite in sexually-dimorphic mAL interneurons in females, and (3) small deletions in the Fru-binding site of robo1 promoter induce a loss of the male-specific neurite and disrupt male courtship patterns. This study paves the way for a thorough understanding of the mechanism whereby Fru proteins orchestrate transcription for the formation of courtship circuitry.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The Drosophila Lingerer protein cooperates with Orb2 in long-term memory formation.2014
Author(s)
Kimura, S., Sakakibara, Y., Sato, K., Ote, M., Ito, H., Koganezawa, M., and Yamamoto, D.
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Journal Title
J. Neurogenet.
Volume: 29
Issue: 1
Pages: 8-17
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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