| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The cortex outputs the information to several brain areas through different sets of pyramidal cells. It has been shown that cortical pyramidal cells form intra- and inter-laminar subnetworks, depending on pyramidal projection subtypes. Cortical fast spiking (FS) interneurons strongly regulate pyramidal cells through perisomatic innervations. Therefore, it is important to know how activities of individual pyramidal cell subnetworks are regulated by FS cells. I investigated connection pattern between FS and pyramidal cells and optogenetically induced network activities in the rat frontal cortical slices. I found that FS cells form connections between pyramidal cells without pyramidal subtype specific manner. However, oscillatory activities at the frequency around 30Hz were observed in specific pyramidal subtypes and FS cells during light stimulations. These results suggest that FS cells play important roles in regulation of excitatory cell subnetworks.
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