Connection specificity between cortical pyramidal cells and FS interneurons
| Project/Area Number |
25430019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
OTSUKA Takeshi 生理学研究所, 基盤神経科学研究領域, 助教 (10390692)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大脳皮質 / 錐体細胞 / FS細胞 |
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| Outline of Final Research Achievements |
The cortex outputs the information to several brain areas through different sets of pyramidal cells. It has been shown that cortical pyramidal cells form intra- and inter-laminar subnetworks, depending on pyramidal projection subtypes. Cortical fast spiking (FS) interneurons strongly regulate pyramidal cells through perisomatic innervations. Therefore, it is important to know how activities of individual pyramidal cell subnetworks are regulated by FS cells. I investigated connection pattern between FS and pyramidal cells and optogenetically induced network activities in the rat frontal cortical slices. I found that FS cells form connections between pyramidal cells without pyramidal subtype specific manner. However, oscillatory activities at the frequency around 30Hz were observed in specific pyramidal subtypes and FS cells during light stimulations. These results suggest that FS cells play important roles in regulation of excitatory cell subnetworks.
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Report
(4 results)
Research Products
(8 results)
