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A role of Plexin A2/A4 signaling in layer formation of the mouse cerebral cortex

Research Project

Project/Area Number 25430020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

HATANAKA Yumiko  生理学研究所, 基盤神経科学研究領域, 特別協力研究員 (40271548)

Co-Investigator(Kenkyū-buntansha) 平田 たつみ  国立遺伝学研究所, 総合遺伝研究系, 教授 (80260587)
川崎 能彦  国立遺伝学研究所, 総合遺伝研究系, 助教 (00322751)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経発生 / 細胞移動 / 層形成 / 大脳皮質形成 / 細胞間相互作用 / 解剖学 / 発生・分化 / 脳・神経 / 神経細胞移動 / 発生•分化
Outline of Final Research Achievements

We investigated a phenotype of Plexin A2/A4 double mutant mouse, in which a fraction of upper layer neurons of the cerebral cortex failed to terminate migration and ectopically invaded layer 1. PlexinA2/A4 proteins were expressed on leading processes of upper layer neurons and rescue experiment indicated that Plexin A2/A4 played a cell-autonomous role. On the other hand, Semaphorin 6A, the ligand for Plexin A2/A4, was concentrated in layer 1 and found to originate from radial glial cells in the ventricular zone. These results provide a novel model for termination of neuronal migration; (1) neurons migrate along radial glial cell fiber to reach the top of the cortical plate, (2) Plexin A2/A4-positive leading process touch the distal part of radial glial cell fiber in layer 1, which expresses Semaphorin 6A, and (3) probably due to repulsive effect, interaction between these molecules leads to detachment of migrating neurons from their substrate, thereby terminating migration.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain2016

    • Author(s)
      Yumiko Hatanaka, Yan Zhu, Makio Torigoe, Yoshiaki Kita, Fujio Murakami
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 92 Issue: 1 Pages: 1-19

    • DOI

      10.2183/pjab.92.1

    • NAID

      130005118553

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neuronal polarization in the developing cerebral cortex2015

    • Author(s)
      Akira Sakakibara
    • Journal Title

      Front. Neurosci.

      Volume: 9 Pages: 116-116

    • DOI

      10.3389/fnins.2015.00116

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cortical divergent projections in mice originate from two sequentially generated, distinct populations of excitatory cortical neurons with different initial axonal outgrowth characteristics.2015

    • Author(s)
      Hatanaka, Y., Namikawa, T., Yamauchi, K., & Kawaguchi, Y.
    • Journal Title

      Cereb. Cortex

      Volume: - Issue: 5 Pages: 2257-2270

    • DOI

      10.1093/cercor/bhv077

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Proper termination of migration for uppermost part of layers 2/3 neurons requires PlexinA2/A4-Semaphorin6A signaling in the mouse cerebral cortex2016

    • Author(s)
      Y. Hatanaka, T. Kawasaki, Y. Kawaguchi, T. Hirata
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plexin A2/A4-Semaphorin 6A signaling is involved in termination of migration for uppermost layer neurons in the mouse cerebral cortex2016

    • Author(s)
      Yumiko Hatanaka, Takahiko Kawasaki, Tatsumi Hirata, Yasuo Kawaguchi
    • Organizer
      International Symposium on Adaptive Circuit Shift 2016 (ACS2016)
    • Place of Presentation
      同志社大学 寒梅館(京都府上京区)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] PlexinA2/A4 signaling is necessary for proper termination of migration for uppermost part of layers 2/3 neurons in the mouse cerebral cortex2016

    • Author(s)
      Yumiko Hatanaka, Takahiko Kawasaki, Tatsumi Hirata, Yasuo Kawaguchi
    • Organizer
      新学術領域「大脳新皮質構築」終了公開国際シンポジウム
    • Place of Presentation
      東京大学 小柴ホール(東京都文京区)
    • Year and Date
      2016-02-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 生理学研究所 大脳神経回路論研究部門ホームページ

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Remarks] 生理学研究所 大脳神経回路論研究部門ホームページ

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2021-01-27  

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