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Mechanisms of basal ganglia control of thalamocortical activity

Research Project

Project/Area Number 25430021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

CHIKEN Satomi  生理学研究所, システム脳科学研究領域, 助教 (30396262)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords大脳基底核 / 視床 / 運動制御 / 神経活動 / サル / 神経活動記録 / マカクサル / 大脳皮質
Outline of Final Research Achievements

The basal ganglia receive inputs from the cerebral cortices and project back to the original cortices via the thalamus, and control voluntary movements. Thus, for elucidating roles of these structures on voluntary movements, it is crucial to understand how their outputs control thalamocortical activity. We recorded activity of identified thalamocortical neurons projecting to the motor cortices of macaque monkeys, and examined responses to electrical stimulation of the internal segment of the globus pallidus (GPi), output nucleus of the basal ganglia.
During repetitive GPi stimulation at 50 or 100 Hz, each stimulus pulse evoked short-latency inhibition and following excitation. Local injection of gabazine, GABA-A receptor antagonist, in the vicinity of recorded neurons abolished both the inhibition and excitation without significant changes of spontaneous firing. The results suggest that basal ganglia outputs convey information through postinhibitory rebound excitation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Dopamine D1 receptor-mediated transmission maintains information flow through the cortico-striato-entopeduncular direct pathway to release movements.2015

    • Author(s)
      Chiken S, Sato A, Ohta C, Kurokawa M, Arai S, Maeshima J, Sunayama-Morita T, Sasaoka T, Nambu A
    • Journal Title

      Cerebral Cortex

      Volume: 25 Issue: 12 Pages: 4885-4897

    • DOI

      10.1093/cercor/bhv209

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MechanismDeep Brain Stimulation: Inhibition, Excitation or Disruption?2015

    • Author(s)
      Chiken S, Nambu A
    • Journal Title

      Neuroscientist

      Volume: in press Issue: 3 Pages: 313-322

    • DOI

      10.1177/1073858415581986

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Parkinson’s disease as a network disorder2016

    • Author(s)
      Chiken S, Nambu A
    • Organizer
      第93回日本生理学会大会シンポジウム「ネットワーク病としての神経・精神疾患」
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Correlated pallidal activity during voluntary reaching movements in a macaque monkey2015

    • Author(s)
      Woranan W, Chiken S, Nambu A
    • Organizer
      8th FAPOS Congress
    • Place of Presentation
      Centara Grand & Bangkok Convention Centre at CentralWorld (Thailand Bangkok)
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basal ganglia and cerebellar control of thalamocortical activity2015

    • Author(s)
      Chiken S, Sano H, Kawaguchi Y, Kimura M, Nambu A
    • Organizer
      8th FAPOS Congress
    • Place of Presentation
      Centara Grand & Bangkok Convention Centre at CentralWorld (Thailand Bangkok)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pallidal and cerebellar control of thalamocortical activity2015

    • Author(s)
      Chiken S, Nambu A
    • Organizer
      5th NIPS-CIN Joint Symposium
    • Place of Presentation
      生理学研究所(愛知県 岡崎)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大脳基底核は、どのように運動を制御しているのか?2015

    • Author(s)
      知見聡美
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      品川プリンスホテル(東京都 品川)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核による視床-大脳皮質投射の制御機構2015

    • Author(s)
      知見聡美、南部篤
    • Organizer
      第5回名大-生理研合同シンポジウム
    • Place of Presentation
      生理学研究所(愛知県 岡崎)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病モデルサルにおける大脳皮質-大脳基底核回路における情報伝達の異常2015

    • Author(s)
      知見聡美、南部篤
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県 神戸)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病モデルサルにおける大脳皮質-大脳基底核路の情報伝達異常2015

    • Author(s)
      知見聡美、南部篤
    • Organizer
      第9回 Motor Control 研究会
    • Place of Presentation
      京都大学時計台講堂国際交流ホール(京都府 京都)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pallidal and cerebellar control of thalamocortical activity2015

    • Author(s)
      Chiken S, Nambu A
    • Organizer
      神経オシレーションカンファレンス
    • Place of Presentation
      京都大学時計台講堂国際交流ホール(京都府 京都)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大脳基底核-視床-大脳皮質投射による運動制御機構2014

    • Author(s)
      知見聡美
    • Organizer
      大脳基底核機能研究会
    • Place of Presentation
      愛知県、岡崎、生理学研究所
    • Year and Date
      2014-12-25 – 2014-12-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 大脳基底核と小脳は、どのように視床-大脳皮質投射を制御しているのか2014

    • Author(s)
      知見聡美
    • Organizer
      生理研研究会-大脳皮質を中心とした神経コネクトミクストその動的特性を探る
    • Place of Presentation
      愛知県、岡崎、岡崎カンファレンスセンター
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Pallidal and cerebellar control of thalamocortical activity.2014

    • Author(s)
      Chiken S, Kawaguchi Y, Kimura M, Nambu A
    • Organizer
      Neuroscience 2014, SfN’s 44th annual meeting
    • Place of Presentation
      米国、Washington DC
    • Year and Date
      2014-11-15 – 2014-11-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional role of dopamine D1 and D2 receptors in information processing through the basal ganglia2013

    • Author(s)
      Satomi Chiken
    • Organizer
      NIPS Mini-International Symposium, Okazaki
    • Place of Presentation
      自然科学研究機構生理学研究所(愛知)
    • Related Report
      2013 Research-status Report
  • [Presentation] What is dopamine telling striatal neurons through D1 and D2 receptors?2013

    • Author(s)
      Satomi Chiken
    • Organizer
      1st Joint Chulalongkon-NIPS Symposium, Bangkok
    • Place of Presentation
      Bangkok(Thailand)
    • Related Report
      2013 Research-status Report
  • [Presentation] 小脳入力と大脳基底核入力の視床-大脳皮質投射への作用2013

    • Author(s)
      知見聡美、川口泰雄、木村 實、南部 篤
    • Organizer
      第28回日本大脳基底核研究会
    • Place of Presentation
      ラフォーレ修善寺(静岡)
    • Related Report
      2013 Research-status Report
  • [Presentation] Differential information processing through the basal ganglia-thalamo-cortical and cerebello-thalamo-cortical pathways2013

    • Author(s)
      知見聡美、川口泰雄、木村 實、南部 篤
    • Organizer
      日本比較生理生化学第35回大会
    • Place of Presentation
      イーグレ姫路(兵庫)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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