| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The physiological and structural changes upon synapses are underlying memory formation. Recent studies suggest that dopamine plays important role for the plastic change. However it is unclear which molecular pathway is activated by dopamine and how dopamine is released during memory formation. Previously, I successfully induced plastic change in the synaptic transmission between olfactory central and mushroom body, olfactory memory core, in the isolated Drosophila brain. We used the isolated brain system and found that dopamine signaling phosphorylates various molecules in the mushroom body. Moreover, we found that dopamine release during memory formation is regulated not only dopaminergic neurons but also mushroom body neurons.
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