The physiological and biochemical studies of short-lasting memory
| Project/Area Number |
25430029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
UENO Kohei 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (40332556)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ショウジョウバエ / 神経可塑性 / ドパミン / 記憶形成 / プロテオーム解析 |
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| Outline of Final Research Achievements |
The physiological and structural changes upon synapses are underlying memory formation. Recent studies suggest that dopamine plays important role for the plastic change. However it is unclear which molecular pathway is activated by dopamine and how dopamine is released during memory formation. Previously, I successfully induced plastic change in the synaptic transmission between olfactory central and mushroom body, olfactory memory core, in the isolated Drosophila brain. We used the isolated brain system and found that dopamine signaling phosphorylates various molecules in the mushroom body. Moreover, we found that dopamine release during memory formation is regulated not only dopaminergic neurons but also mushroom body neurons.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Glial dysfunction causes age-related memory impairment in Drosophila.2014
Author(s)
Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi Y, Isobe T, Honda Y, Kodama T, Masuda T, Saitoe M
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Journal Title
Neuron
Volume: 84
Pages: 753-763
Related Report
Peer Reviewed
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