| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The amygdaloid network is a principal component of the limbic system with roles in emotion, feeding and sexual behavior. Axons of distinct amygdaloid nuclei connect to the bed nucleus of the stria terminalis (BNST) in a topographic manner. However, it remains largely unknown the roles or contributions of this topographic connections for animal behavior. We have tried to generate the network modification animal restricted in amygdala-BNST connections. We generated the conditional targeting vectors for three axon guidance genes (plexin-A4, Sema6A. Sema6B), regulating the formation of the topographic connection, and established two ES cell lines with targeted recombination for plexin-A4.
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