Developmental process of cerebellar compartmentalization and topographic axonal projections as basis for cerebellar functional localization
| Project/Area Number |
25430032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUGIHARA Izumi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60187656)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マウス / 小脳 / 縦縞状区画構造 / Pcdh10 / レポーターマウス / 形成過程 / プルキンエ細胞 / プロトカドヘリン10 / 軸索投射 / アルドラーゼC / 神経解剖学 / 下オリーブ核 / 遺伝子改変マウス / 軸索再構築 |
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| Outline of Final Research Achievements |
We analyzed the process of formation of the cerebellar compartmentalization and topographic axonal projection, which are important for varieties of cerebellar functions such as the control of many motor activities. Seven compartments elongated in the rostrocaudal direction were recognized in the early cerebellum at the embryonic day 14.5 (E14.5). The process in which these compartments were separated and divided into some 50 compartments in three days by E17.5 was clarified in the three-dimensional space. It was also observed that topographic axonal connection was formed first in the cerebellar nuclei, which then leads to compartmentalization. Results obtained in the related research projects were published in five research papers in international academic journals with the principal investigator as the corresponding author during the three-year period of the grant support. However, some central results are still under preparation for publication.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Systematic regional variations in Purkinje cell spiking patterns.2014
Author(s)
Xiao J, Cerminara NL, Kotsurovskyy Y, Aoki H, Burroughs A, Wise AK, Luo Y, Marshall SP, Sugihara I, Apps R, Lang EJ
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Journal Title
PLoS ONE
Volume: 9
Issue: 8
Pages: e105633-e105633
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] アルドラーゼC発現の縞構造と登上線維投射の部位対応性に基づいたトリ小脳の区画構造2014
Author(s)
Yuanjun Luo, Suteera Vibulyaseck, Hirofumi Fujita, Hiroko Ohki-Hamazaki, and Izumi Sugihara
Organizer
平成26年度『包括型脳科学研究推進支援ネットワーク』冬のシンポジウム
Place of Presentation
東京医科歯科大学、ホテル東京ガーデンパレス、東京都文京区
Year and Date
2014-12-11 – 2014-12-13
Related Report
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[Presentation] Development of functional compartmentalization of the cerebellum2014
Author(s)
Suteera Vibulyaseck, Shinji Hirano, Izumi Sugihara
Organizer
Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong
Place of Presentation
Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China
Year and Date
2014-06-12 – 2014-06-14
Related Report
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