Role of protocadherin 9 in formation of the occulomotor system

• Project/Area Number: 25430037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kansai Medical University (2014-2015); Kochi University (2013)
• Principal Investigator: HIRANO Shinji 関西医科大学, 医学部, 教授 (80222248)
• Co-Investigator(Kenkyū-buntansha): YURI Kazunari 高知大学, 医学部, 教授 (10220534)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: プロトカドヘリン / カドヘリン / 神経回路 / 動眼反射 / 平衡覚 / 細胞接着分子 / 精神神経疾患 / 神経回路形成

Outline of Final Research Achievements

Protocadherin 9 is expressed in the vestibular and oculomotor systems, but its physiological role is not known. In this study, we examined if this molecule is involved in formation of these systems and in sense of balance in the protocadherin 9-knock-out mice. We could not detect any abnormalities in formation of the neural circuits during development in histochemical analyses. On the other hand, we found abnormal behaviors in optokinetic response (OKR) and higher emotional response. These results showed that protocadherin 9 plays some roles in neural functions in the vestibular and oculomotor systems and the emotional system.

Research Products

• [Journal Article] Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex. (2016)
  • Author(s): Oishi, K, Nakajima, K
  • Journal Title: eLife Volume: 5 Pages: 1-26
  • DOI: 10.7554/elife.10907
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PCDH10 is required for the tumorigenicity of glioblastoma cells (2014)
  • Author(s): Kanae Echizen, Mitsutoshi Nakada , Tomoatsu Hayashi, Hemragul Sabit, Takuya Furuta, Miyuki Nakai, Ryo Koyama-Nasu, Yukiko Nishimura, Kenzui Taniue, Yasuyuki Morishita, Shinji Hirano, Kenta Terai, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Shunsaku Takayanagi, Ryohei Ohtani, Nobuhito Saito, Tetsu Akiyama
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 444 Issue: 1 Pages: 13-18
  • DOI: 10.1016/j.bbrc.2013.12.138
  • Peer Reviewed / Open Access
• [Journal Article] Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. (2014)
  • Author(s): Lu KM, Evans SM, Hirano S, Liu FC.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 111 Issue: 1
  • DOI: 10.1073/pnas.1319138111
  • Peer Reviewed
• [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits (2013)
  • Author(s): Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
  • Journal Title: Neuron Volume: 78(5) Issue: 5 Pages: 839-854
  • DOI: 10.1016/j.neuron.2013.03.031
  • Peer Reviewed
• [Presentation] Early development of the longitudinal striped compartments in the prenatal mouse cerebellum studied with three-dimensional mapping of protocadherin 10 expression (2016)
  • Author(s): Suteera Vibulyaseck, Gideon Sarpong, Hirofumi Fujita, Shinji Hirano, Izumi Sugihara
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-07-24
• [Presentation] Comparison of expression patterns of different marker molecules of the cerebellar longitudinal striped compartments in the mouse. (2016)
  • Author(s): Authors Gideon Anokye Sarpong, Hirofumi Fujita, Suteera Vibulyaseck, Teiichi Furuichi, Shinji Hirano, Izumi Sugihara
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-07-24
• [Presentation] Male-specific dendritic spine abnormalities in amygdala of mice haploinsufficient for Protocadherin 10, an autism-associated gene (2015)
  • Author(s): H. Schoch1, A. Banerjee, S. Ferri1, A. Kreibich, H. Dow, S. Hirano, R.T. Schultz, C.G. Hahn, T. Abel1, E. Brodkin, D. Feldmeyer
  • Organizer: Annual Meeting for Society of Neuroscience
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] 非定型カドヘリンの多様性と機能
  • Author(s): 平野伸二
  • Organizer: 日本生化学会大会
  • Place of Presentation: 横浜
• [Book] Chapter 1 Introduction (Book title " the Cadherin Superfamily") (2016)
  • Author(s): Shintaro T. Suzuki & Shinji Hirano
  • Total Pages: 9
  • Publisher: Springer Japan
• [Book] Chapter 11 Various Atypical Cadherins: T-Cadherin, RET, Calsyntenin, and 7D Cadherin (Book title " the Cadherin Superfamily") (2016)
  • Author(s): Keiko Imai-Okano and Shinji Hirano
  • Total Pages: 35
  • Publisher: Springer Japan
• [Book] Chapter 15 Cadherin-Related Diseases (Book title " the Cadherin Superfamily") (2016)
  • Author(s): Shinji Hirano and Keiko Imai-Okano
  • Total Pages: 23
  • Publisher: Springer Japan