| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Protocadherin 9 is expressed in the vestibular and oculomotor systems, but its physiological role is not known. In this study, we examined if this molecule is involved in formation of these systems and in sense of balance in the protocadherin 9-knock-out mice. We could not detect any abnormalities in formation of the neural circuits during development in histochemical analyses. On the other hand, we found abnormal behaviors in optokinetic response (OKR) and higher emotional response. These results showed that protocadherin 9 plays some roles in neural functions in the vestibular and oculomotor systems and the emotional system.
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