Expression and functional roles of HMGB family in adult neurogenesis

Research Project

Project/Area Number	25430039
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Nerve anatomy/Neuropathology
Research Institution	Kyoto Prefectural University of Medicine (2016) Fukushima Medical University (2013-2015)
Principal Investigator	Imura Tetsuya 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00405276)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	神経幹細胞 / 神経新生 / 神経再生
Outline of Final Research Achievements	HMGB2, a member of high-mobility group box protein (HMGB) family, is selectively expressed in adult neurogenic regions. Neural stem cells and neural progenitors highly express HMGB2, but its expression disappears after neuronal maturation. Knockdown and forced expression of HMGB2 indicate that it regulates survival and maturation of newborn cells. We also identify that nuclear orphan receptor Nr4a2 is highly expressed in embryonically-generated, but not in adult-generated granule cells, in hippocampal dentate gyrus. Nr4a2 expression in granule cells is linked to environmental stress exposure, suggesting its role in neurogenesis-related stress response and memory formation.