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Expression and functional roles of HMGB family in adult neurogenesis

Research Project

Project/Area Number 25430039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyoto Prefectural University of Medicine (2016)
Fukushima Medical University (2013-2015)

Principal Investigator

Imura Tetsuya  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00405276)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経幹細胞 / 神経新生 / 神経再生
Outline of Final Research Achievements

HMGB2, a member of high-mobility group box protein (HMGB) family, is selectively expressed in adult neurogenic regions. Neural stem cells and neural progenitors highly express HMGB2, but its expression disappears after neuronal maturation. Knockdown and forced expression of HMGB2 indicate that it regulates survival and maturation of newborn cells.
We also identify that nuclear orphan receptor Nr4a2 is highly expressed in embryonically-generated, but not in adult-generated granule cells, in hippocampal dentate gyrus. Nr4a2 expression in granule cells is linked to environmental stress exposure, suggesting its role in neurogenesis-related stress response and memory formation.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2017 2014

All Presentation (2 results)

  • [Presentation] 海馬神経新生のダイナミクスと“老若”ニューロンの分子特性2017

    • Author(s)
      錫谷 研
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 成体神経幹細胞におけるHMGBファミリーの発現と機能解析2014

    • Author(s)
      小林靖幸
    • Organizer
      日本病理学会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report 2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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