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Analysis of embryonic-to-adult transition in neural progenitors of the hippocampal granule cells

Research Project

Project/Area Number 25430041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Medical University

Principal Investigator

Seki Tatsunori  東京医科大学, 医学部, 教授 (20175417)

Co-Investigator(Kenkyū-buntansha) Kashiwagi Taichi  東京医科大学, 医学部, 助教 (10398232)
Shinohara Hiroshi  東京医科大学, 医学部, 助教 (10455793)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords海馬 / 神経幹細胞 / 成体脳ニューロン新生 / ニューロン分化 / 移動 / シグナル分子 / 顆粒細胞 / GFAP / BLBP / ニューロン新生 / 歯状回 / 胎生期
Outline of Final Research Achievements

In the hippocampus, neurons continue to be generated even in adults. The phenomenon of adult neurogenesis raises hopes of regenerating injured brain tissue. In order to understand the persistent neuronal production, we investigate the embryonic-to-postnatal transition of neurogenesis in the hippocampus. We found that the property of neural progenitors is different between embryonic and early postnatal stages. Postnatal and adult progenitors express two stem cell-related proteins, GFAP and BLBP, but embryonic ones express GFAP only. Furthermore, cells surrounding the neurogenic region play an important role in the neurogenesis. They secrete a morphogen, CXCL12, while progenitors have the receptor, CXCR4. The inhibition of the signaling affects differentiation and migration of progenitors. These results suggest that the persistent neurogenesis is involved in alteration of the property of progenitors and a signal molecule secreted by supporting cells around the neurogenic region.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (18 results) Remarks (3 results)

  • [Journal Article] Neural stem cells and neuro/gliogenesis in the central nervous system: understanding the structural and functional plasiticity of the deveroping, mature, and diseased brain.2016

    • Author(s)
      Yamaguchi M, Seki T, Imayoshi I, Tamamaki N, Hayashi Y, Tatebayashi Y, Hitoshi S.
    • Journal Title

      Journal of Physiological Science

      Volume: 66(3) Issue: 3 Pages: 197-206

    • DOI

      10.1007/s12576-015-0421-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus.2014

    • Author(s)
      Seki, T., Sato, T., Toda, K., Osumi, N., Imura, T. and Shioda, S.
    • Journal Title

      Journal of Comparative Neurology.

      Volume: 522(2) Issue: 2 Pages: 261-283

    • DOI

      10.1002/cne.23460

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 成体脳におけるニューロン新生2013

    • Author(s)
      石龍徳
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 1389-1391

    • Related Report
      2013 Research-status Report
  • [Presentation] Regulation of apical dendritic patterning of upper-layers neurons in the neocortex2016

    • Author(s)
      Gonda Y, Seki T, Hanashima C
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞移動を基軸とする海馬歯状回形成のメカニズム探索2016

    • Author(s)
      篠原広志, 塩田清二, 石龍徳
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胎生期海馬歯状回形成過程におけるBMPシグナルの役割2016

    • Author(s)
      柏木太一, 塩田清二, 石龍徳
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] BMP signaling induce Gfap-expressing NSCs which restrictedly exist in the developing hippocampus2015

    • Author(s)
      Kashiwagi T, Shioda S, Seki T
    • Organizer
      日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cell-tracing analysis for progenitor cell migration in the embryonic dentate gyrus2015

    • Author(s)
      Shinohara H, Shioda S, Seki T
    • Organizer
      日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] The role of BMP in the process of the developing dentate gyrus2015

    • Author(s)
      Kashiwagi T, Shioda S, Seki T
    • Organizer
      The 120th Annual meeting of the Japanese association of anatomists
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Cell-tracing analysis for progenitor cell migraion in the embryonic dentate gyrus2015

    • Author(s)
      Shinohara H, Shioda S, Seki T
    • Organizer
      The 120th Annual meeting of the Japanese association of anatomists
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-24
    • Related Report
      2014 Research-status Report
  • [Presentation] From embryonic to adult neurogenesis in the hippocampus2015

    • Author(s)
      Seki T
    • Organizer
      The 120th Annual meeting of the Japanese association of anatomists
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Selective vulnerability and dispersion of dentate granule cells and their progenitors in pilocarpine-induced status epilepticus rat model2014

    • Author(s)
      Uemori T, Toda K, Seki T
    • Organizer
      The 37th Annual meeting of the Japan neuroscience society
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] BMP signaling propel production of Gfap-expressing NSCs existed in developing hippocampus2014

    • Author(s)
      Kashiwagi T, Shioda S, Seki T
    • Organizer
      The 37th Annual meeting of the Japan neuroscience society
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] The property of dentate granule cell progenitors is altered immediately after birth2014

    • Author(s)
      Seki T, Minakawa S, Sato T, Toda K, Iwamuro S, Shioda S
    • Organizer
      The 37th Annual meeting of the Japan neuroscience society
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Cell-tracing analysis for progenitor cell migration in the embryonic dentate gyrus2014

    • Author(s)
      Shinohara H, Sato T, Toda K, Shioda S, Seki T
    • Organizer
      The 37th Annual meeting of the Japan neuroscience society
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯状回の顆粒細胞を産生するGfap発現前駆細胞の性質は周生期に変化する

    • Author(s)
      石龍徳、皆川史織、佐藤亨、戸田景子、岩室祥一、塩田清二
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] BMPシグナルは胎生期海馬に存在するGFAPを発現する神経幹細胞の産生に重要である

    • Author(s)
      柏木太一、塩田清二、石龍徳
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 胎生期海馬神経前駆細胞の移動解析

    • Author(s)
      篠原広志、佐藤亨、戸田景子、塩田清二
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 海馬型神経幹細胞はBMPシグナルによって誘導される

    • Author(s)
      柏木太一、塩田清二、石龍徳
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
  • [Presentation] 海馬の顆粒細胞の神経幹細胞/前駆細胞は出生直後に性質を変化させる

    • Author(s)
      石龍徳、皆川史織、佐藤亨、戸田景子、上森健至、岩室祥一、塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞移動を基軸とする海馬枝上回形成のメカニズム探索

    • Author(s)
      篠原広志、佐藤亨、戸田景子、塩田清二、石龍徳
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
  • [Remarks] 組織・神経解剖学

    • URL

      http://www.tokyo-med.ac.jp/faculty/med/course/course10.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 東京医科大学組織・神経解剖学

    • URL

      http://www.tokyo-med.ac.jp/Histology-Neuroanatomy/Histology-Neuroanatomy/home.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 石龍徳研究グループ

    • URL

      http://members3.jcom.home.ne.jp/sekitatsunori/seki-G/home.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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