Analysis of embryonic-to-adult transition in neural progenitors of the hippocampal granule cells
| Project/Area Number |
25430041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kashiwagi Taichi 東京医科大学, 医学部, 助教 (10398232)
Shinohara Hiroshi 東京医科大学, 医学部, 助教 (10455793)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 海馬 / 神経幹細胞 / 成体脳ニューロン新生 / ニューロン分化 / 移動 / シグナル分子 / 顆粒細胞 / GFAP / BLBP / ニューロン新生 / 歯状回 / 胎生期 |
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| Outline of Final Research Achievements |
In the hippocampus, neurons continue to be generated even in adults. The phenomenon of adult neurogenesis raises hopes of regenerating injured brain tissue. In order to understand the persistent neuronal production, we investigate the embryonic-to-postnatal transition of neurogenesis in the hippocampus. We found that the property of neural progenitors is different between embryonic and early postnatal stages. Postnatal and adult progenitors express two stem cell-related proteins, GFAP and BLBP, but embryonic ones express GFAP only. Furthermore, cells surrounding the neurogenic region play an important role in the neurogenesis. They secrete a morphogen, CXCL12, while progenitors have the receptor, CXCR4. The inhibition of the signaling affects differentiation and migration of progenitors. These results suggest that the persistent neurogenesis is involved in alteration of the property of progenitors and a signal molecule secreted by supporting cells around the neurogenic region.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] A distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus2014
Author(s)
Seki, T., Sato, T., Toda, K., Osumi, N., Imura, T. and Shioda, S.
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Journal Title
J Comp Neurol
Volume: 522(2)
Pages: 261-283
DOI
Related Report
Peer Reviewed
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