Analysis of neural circuit regulating proliferation of neural precursor cells in the adult SVZ
| Project/Area Number |
25430044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tottori University (2014-2015)
Kansai Medical University (2013) |
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Principal Investigator |
Mori Tetsuji 鳥取大学, 医学部, 教授 (30285043)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA Masayoshi 倉敷芸術科学大学, 生命科学部, 教授 (40334677)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 成体ニューロン新生 / 神経幹細胞 / 神経回路 / 神経伝達物質 / 細胞増殖 / ニューロンの興奮 |
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| Outline of Final Research Achievements |
The subventricular zone (SVZ) in the adult mammalian brain contains neural precursor cells. And it is known that excessive neuronal excitation induces proliferation of neuronal precursor cells. In this study, we showed that epigenetic gene expression is induced in the striatal neurons close to the SVZ immediately after induction of status epilepticus in adult mice. It was suggested that the gene expression change in those neurons led to remodeling of micro-neuronal circuit around the neural precursor cells, and neuronal circuit affects proliferation of neural precursor cells.
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Report
(4 results)
Research Products
(24 results)
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[Presentation] 鶏胚脊髄オリゴデンドロサイトO4抗原の実態解析2014
Author(s)
平原幸恵, 若林毅俊, 森徹自, 小池太郎, 高森康晴, 矢尾育子, 伊藤誠二, 後藤仁志, 本家孝一, 小野勝彦, 山田久夫
Organizer
第119回日本解剖学会総会・全国学術集会
Place of Presentation
自治医科大学（栃木）
Related Report
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