Mechanism for establishment of the callosal axons from late born cortical neurons

• Project/Area Number: 25430046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: Tabata Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 室長 (80301761)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経回路形成 / 神経発生 / 大脳皮質 / 神経幹細胞 / 神経細胞移動 / 神経回路

Outline of Final Research Achievements

In mammals, the cortical neurons are produced either directly from the neural stem cells in the VZ or secondary proliferative cells in the SVZ. We have previously reported that these two populations undergo distinct migratory behaviors in the late cortical plate development. The former accumulated in the lower SVZ, and then extended callosal axons medially. On the other hand, the latter did not accumulate as seen in the former, but spread widely in the SVZ. In this research project, we hypothesized that these two populations establish distinct axonal connectivity, especially regarding callosal axons. We identified a key gene regulating the production of SVZ-proliferative cells. Overexpression of this molecule enhanced the production of SVZ-proliferative cells. Immunohistochemical analysis revealed that it was expressed in the SVZ-proliferative cells themselves. The further observations how the overexpression of this molecule alter the neural networks are needed.

Research Products

• [Journal Article] Role of a circadian-relevant gene NR1D1 in brain development: possible involvement in the pathophysiology of autism spectrum disorders. (2017)
  • Author(s): Goto, M., Mizuno, M., Matsumoto, A., Yang, Z., Jimbo, E.F., Tabata, H., Yamagata, T., Nagata, K.-I.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 43945-43945
  • DOI: 10.1038/srep43945
  • Peer Reviewed / Open Access
• [Journal Article] Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex. (2017)
  • Author(s): Inoue M, Iwai R, Tabata H, Konno D, Komabayashi-Suzuki M, Watanabe C, Iwanari H, Mochizuki Y, Hamakubo T, Matsuzaki F, Nagata K-I, Mizutani K-I
  • Journal Title: Development Volume: 144 Issue: 3 Pages: 385-399
  • DOI: 10.1242/dev.136382
  • Peer Reviewed
• [Journal Article] Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability. (2016)
  • Author(s): Hamada, N., Negishi, Y., Mizuno, M., Miya, F., Hattori, A., Okamoto, N., Kato, M., Tsunoda, T., Yamasaki, M., Kanemura, Y., Kosaki, K., Tabata, H., Saitoh, S., Nagata, K.-I.
  • Journal Title: J. Neurochem. Volume: 140 Issue: 1 Pages: 82-95
  • DOI: 10.1111/jnc.13878
  • Peer Reviewed
• [Journal Article] Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development. (2016)
  • Author(s): Hamada N, Ito H, Nishijo T, Iwamoto I, Morishita R, Tabata H, Momiyama T, Nagata K-I
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 30805-30805
  • DOI: 10.1038/srep30805
  • Peer Reviewed / Open Access
• [Journal Article] Morphological characterization of Class III phosphoinositide 3-kinase during mouse brain development. (2016)
  • Author(s): Inaguma Y, Ito H, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K-I
  • Journal Title: Med Mol Morphol Volume: 49 Issue: 1 Pages: 28-33
  • DOI: 10.1007/s00795-015-0116-1
  • Peer Reviewed / Open Access
• [Journal Article] Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex. (2015)
  • Author(s): Hamada N, Ito H, Iwamoto I, Morishita R, Tabata H, Nagata K-I
  • Journal Title: Molecular Autism Volume: 6 Issue: 1 Pages: 56-56
  • DOI: 10.1186/s13229-015-0049-5
  • Peer Reviewed / Open Access
• [Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain (2015)
  • Author(s): Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 112(36) Issue: 36
  • DOI: 10.1073/pnas.1420701112
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Analysis of cardiomyocyte movement in the developing murine heart. (2015)
  • Author(s): Hashimoto H, Yuasa S, Tabata H, Tohyama S, Seki T, Egashira T, Hayashiji N, Hattori F, Kusumoto D, Kunitomi A, Takei M, Kashimura S, Yozu G, Shimojima M, Motoda C, Muraoka N, Nakajima K, Sakaue-Sawano A, Miyawaki A, Fukuda K
  • Journal Title: Biochem Biophys Res Commun Volume: 464 Issue: 4 Pages: 1000-1007
  • DOI: 10.1016/j.bbrc.2015.07.036
  • Peer Reviewed / Open Access
• [Journal Article] Morphological characterization of mammalian Timeless in the mouse brain development. (2015)
  • Author(s): Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K.
  • Journal Title: Neurosci Res Volume: 92 Pages: 21-28
  • DOI: 10.1016/j.neures.2014.10.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. (2015)
  • Author(s): Mizuno M, Matsumoto A, Hamada N, Ito H, Miyauchi A, Jimbo EF, Momoi MY, Tabata H, Yamagata T, Nagata K.
  • Journal Title: J Neurochem Volume: 132 Issue: 1 Pages: 61-69
  • DOI: 10.1111/jnc.12943
  • Peer Reviewed / Open Access
• [Journal Article] Diverse subtypes of astrocytes and their development during corticogenesis. (2015)
  • Author(s): Hidenori Tabata
  • Journal Title: Front. Neurosci. Volume: 9 Pages: 114-114
  • DOI: 10.3389/fnins.2015.00114
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte. (2014)
  • Author(s): Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
  • Journal Title: J.Mol. Cell. Cardiol. Volume: S0022-2828(14) Pages: 97-2
  • DOI: 10.1016/j.yjmcc.2014.03.020
  • Peer Reviewed
• [Journal Article] Roles of Rho small GTPases in the tangentially migrating neurons. (2014)
  • Author(s): Hidenori Ito, Rika Morishita, Hidenori Tabata, and Koh-ichi Nagata
  • Journal Title: Histol. Histopathol. Volume: 29(7) Pages: 871-879
  • Peer Reviewed
• [Journal Article] SIL1, a causative cochaperone gene of Marinesco-Sjogren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex. (2014)
  • Author(s): Hamada N, Inaguma Y, Tabata H, Iwamoto I, Mizuno M, Nishimura YV, Ito H, Morishita R, Suzuki M, Ohno K, Kumagai T, Nagata K.
  • Journal Title: EMBO Mol Med. Volume: 6 Issue: 3 Pages: 414-29
  • DOI: 10.1002/emmm.201303069
  • Peer Reviewed / Open Access
• [Journal Article] Screening for candidate genes involved in the production of mouse subventricular zone proliferative cells and an estimation of their changes in evolutionary pressure during primate evolution (2013)
  • Author(s): Tabata H, Hachiya T, Nagata K, Sakakibara Y, Nakajima K
  • Journal Title: Front Neuroanat Volume: 7 Pages: 24-24
  • DOI: 10.3389/fnana.2013.00024
  • Peer Reviewed / Open Access
• [Journal Article] Biochemical and morphological characterization of A2BP1 in the neuronal tissue. (2013)
  • Author(s): Hamada N, Ito H, Iwamoto I, Mizuno M, Morishita R, Inaguma Y, Kawamoto S, Tabata H and Nagata K.
  • Journal Title: J Neurosci Res Volume: 91 Issue: 10 Pages: 1303-1311
  • DOI: 10.1002/jnr.23266
  • Peer Reviewed
• [Presentation] 大脳皮質発生過程における２次的神経細胞産生部位としての脳室下帯の成り立ちと脳進化との関連 (2016)
  • Author(s): 田畑秀典
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-12-01
  • Invited
• [Presentation] Erratic migration: a unique migratory behavior of astrocyte progenitors. (2016)
  • Author(s): Tabata H, Sasaki M, Inaguma Y, Ito H, Takebayashi H, Ema M, Ikenaka K, Nagata K, Nakajima K
  • Organizer: Neuroscience 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] グリア前駆細胞の移動様式と血管との関連 (2016)
  • Author(s): 田畑秀典、佐々木恵、稲熊裕、伊東秀記、竹林浩秀、依馬正次、池中一裕、 永田浩一、仲嶋一範
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: 郡山(福島県）
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] 皮質脳室帯由来グリア前駆細胞のダイナミックな移動様式(Dynamic behavior of glia progenitors derived from the cortical ventricular zone) (2015)
  • Author(s): 田畑秀典、佐々木恵、稲熊裕、伊東秀記、竹林浩秀、依馬正次、池中一裕、 永田浩一、仲嶋一範
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大 会(BMB2015)
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Interaction between glia and blood vessels during cortical development (2015)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮(埼玉県)
  • Year and Date: 2015-09-11
  • Invited
• [Presentation] Blood vessel-guided cell migration during late cortical plate development (2015)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2015-07-28
• [Presentation] Blood vessel-guided cell migration in the developing cerebral cortex (2015)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: 第48回日本発生生物学会大会
  • Place of Presentation: つくば(茨城県)
  • Year and Date: 2015-06-03
• [Presentation] Functional screening of the candidate genes involving in the expansion of subventricular zone and the evolutionary analysis of them (2015)
  • Author(s): Hidenori Tabata, Tsuyoshi Hachiya, Koh-ichi Nagata, Yasubumi Sakakibara, Kazunori Nakajima
  • Organizer: Cortical Evolution Conference 2015
  • Place of Presentation: Toledo, Spain
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] The unique migratory properties of glial progenitors derived from the cortical ventricular zone（皮質脳室帯由来グリア前駆細胞がとる特徴的な移動様式） (2014)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, Kazunori Nakajima
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] The migration of glial progenitors derived from the cortical ventricular zone (2014)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, Kazunori Nakajima
  • Organizer: Cortical Development Conference 2014
  • Place of Presentation: Crete, Greece
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] Functional screening of the genes involved in the production of progenitor cells in the subventricular zone in mice (2013)
  • Author(s): Hidenori Tabata, Yasubumi Sakakibara, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, California, U.S.A.
• [Presentation] 脳室下帯分裂細胞の産生調節に関わる分子の探索（Screening of the genes involving in the production of progenitor cells in the subventricular zone） (2013)
  • Author(s): 田畑秀典、榊原康文、永田浩一、仲嶋一範
  • Organizer: 第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会（Neuro2013）
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] Histological organization of mouse and primate subventricular zone in the developing cerebral neocortex (2013)
  • Author(s): Hidenori Tabata, Satoshi Yoshinaga, Yasubumi Sakakibara, Koh-ichi Nagata, Kazunori Nakajima
  • Organizer: Neuro2013 Satellite Symposium “Molecular & Cellular Mechanisms of Brain Development & Evolution”
  • Place of Presentation: Kyoto Prefecural University Library Hall, Kyoto