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Mechanism for establishment of the callosal axons from late born cortical neurons

Research Project

Project/Area Number 25430046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

Tabata Hidenori  愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 室長 (80301761)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経回路形成 / 神経発生 / 大脳皮質 / 神経幹細胞 / 神経細胞移動 / 神経回路
Outline of Final Research Achievements

In mammals, the cortical neurons are produced either directly from the neural stem cells in the VZ or secondary proliferative cells in the SVZ. We have previously reported that these two populations undergo distinct migratory behaviors in the late cortical plate development. The former accumulated in the lower SVZ, and then extended callosal axons medially. On the other hand, the latter did not accumulate as seen in the former, but spread widely in the SVZ. In this research project, we hypothesized that these two populations establish distinct axonal connectivity, especially regarding callosal axons. We identified a key gene regulating the production of SVZ-proliferative cells. Overexpression of this molecule enhanced the production of SVZ-proliferative cells. Immunohistochemical analysis revealed that it was expressed in the SVZ-proliferative cells themselves. The further observations how the overexpression of this molecule alter the neural networks are needed.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014 2013

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] Role of a circadian-relevant gene NR1D1 in brain development: possible involvement in the pathophysiology of autism spectrum disorders.2017

    • Author(s)
      Goto, M., Mizuno, M., Matsumoto, A., Yang, Z., Jimbo, E.F., Tabata, H., Yamagata, T., Nagata, K.-I.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 43945-43945

    • DOI

      10.1038/srep43945

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.2017

    • Author(s)
      Inoue M, Iwai R, Tabata H, Konno D, Komabayashi-Suzuki M, Watanabe C, Iwanari H, Mochizuki Y, Hamakubo T, Matsuzaki F, Nagata K-I, Mizutani K-I
    • Journal Title

      Development

      Volume: 144 Issue: 3 Pages: 385-399

    • DOI

      10.1242/dev.136382

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.2016

    • Author(s)
      Hamada, N., Negishi, Y., Mizuno, M., Miya, F., Hattori, A., Okamoto, N., Kato, M., Tsunoda, T., Yamasaki, M., Kanemura, Y., Kosaki, K., Tabata, H., Saitoh, S., Nagata, K.-I.
    • Journal Title

      J. Neurochem.

      Volume: 140 Issue: 1 Pages: 82-95

    • DOI

      10.1111/jnc.13878

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development.2016

    • Author(s)
      Hamada N, Ito H, Nishijo T, Iwamoto I, Morishita R, Tabata H, Momiyama T, Nagata K-I
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 30805-30805

    • DOI

      10.1038/srep30805

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological characterization of Class III phosphoinositide 3-kinase during mouse brain development.2016

    • Author(s)
      Inaguma Y, Ito H, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K-I
    • Journal Title

      Med Mol Morphol

      Volume: 49 Issue: 1 Pages: 28-33

    • DOI

      10.1007/s00795-015-0116-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex.2015

    • Author(s)
      Hamada N, Ito H, Iwamoto I, Morishita R, Tabata H, Nagata K-I
    • Journal Title

      Molecular Autism

      Volume: 6 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s13229-015-0049-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain2015

    • Author(s)
      Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 112(36) Issue: 36

    • DOI

      10.1073/pnas.1420701112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Analysis of cardiomyocyte movement in the developing murine heart.2015

    • Author(s)
      Hashimoto H, Yuasa S, Tabata H, Tohyama S, Seki T, Egashira T, Hayashiji N, Hattori F, Kusumoto D, Kunitomi A, Takei M, Kashimura S, Yozu G, Shimojima M, Motoda C, Muraoka N, Nakajima K, Sakaue-Sawano A, Miyawaki A, Fukuda K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 464 Issue: 4 Pages: 1000-1007

    • DOI

      10.1016/j.bbrc.2015.07.036

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological characterization of mammalian Timeless in the mouse brain development.2015

    • Author(s)
      Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K.
    • Journal Title

      Neurosci Res

      Volume: 92 Pages: 21-28

    • DOI

      10.1016/j.neures.2014.10.017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.2015

    • Author(s)
      Mizuno M, Matsumoto A, Hamada N, Ito H, Miyauchi A, Jimbo EF, Momoi MY, Tabata H, Yamagata T, Nagata K.
    • Journal Title

      J Neurochem

      Volume: 132 Issue: 1 Pages: 61-69

    • DOI

      10.1111/jnc.12943

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diverse subtypes of astrocytes and their development during corticogenesis.2015

    • Author(s)
      Hidenori Tabata
    • Journal Title

      Front. Neurosci.

      Volume: 9 Pages: 114-114

    • DOI

      10.3389/fnins.2015.00114

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.2014

    • Author(s)
      Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
    • Journal Title

      J.Mol. Cell. Cardiol.

      Volume: S0022-2828(14) Pages: 97-2

    • DOI

      10.1016/j.yjmcc.2014.03.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of Rho small GTPases in the tangentially migrating neurons.2014

    • Author(s)
      Hidenori Ito, Rika Morishita, Hidenori Tabata, and Koh-ichi Nagata
    • Journal Title

      Histol. Histopathol.

      Volume: 29(7) Pages: 871-879

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] SIL1, a causative cochaperone gene of Marinesco-Sjogren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex.2014

    • Author(s)
      Hamada N, Inaguma Y, Tabata H, Iwamoto I, Mizuno M, Nishimura YV, Ito H, Morishita R, Suzuki M, Ohno K, Kumagai T, Nagata K.
    • Journal Title

      EMBO Mol Med.

      Volume: 6 Issue: 3 Pages: 414-29

    • DOI

      10.1002/emmm.201303069

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Screening for candidate genes involved in the production of mouse subventricular zone proliferative cells and an estimation of their changes in evolutionary pressure during primate evolution2013

    • Author(s)
      Tabata H, Hachiya T, Nagata K, Sakakibara Y, Nakajima K
    • Journal Title

      Front Neuroanat

      Volume: 7 Pages: 24-24

    • DOI

      10.3389/fnana.2013.00024

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical and morphological characterization of A2BP1 in the neuronal tissue.2013

    • Author(s)
      Hamada N, Ito H, Iwamoto I, Mizuno M, Morishita R, Inaguma Y, Kawamoto S, Tabata H and Nagata K.
    • Journal Title

      J Neurosci Res

      Volume: 91 Issue: 10 Pages: 1303-1311

    • DOI

      10.1002/jnr.23266

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 大脳皮質発生過程における2次的神経細胞産生部位としての脳室下帯の成り立ちと脳進化との関連2016

    • Author(s)
      田畑秀典
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Erratic migration: a unique migratory behavior of astrocyte progenitors.2016

    • Author(s)
      Tabata H, Sasaki M, Inaguma Y, Ito H, Takebayashi H, Ema M, Ikenaka K, Nagata K, Nakajima K
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリア前駆細胞の移動様式と血管との関連2016

    • Author(s)
      田畑秀典、佐々木恵、稲熊裕、伊東秀記、竹林浩秀、依馬正次、池中一裕、 永田浩一、仲嶋一範
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      郡山(福島県)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 皮質脳室帯由来グリア前駆細胞のダイナミックな移動様式(Dynamic behavior of glia progenitors derived from the cortical ventricular zone)2015

    • Author(s)
      田畑秀典、佐々木恵、稲熊裕、伊東秀記、竹林浩秀、依馬正次、池中一裕、 永田浩一、仲嶋一範
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大 会(BMB2015)
    • Place of Presentation
      神戸(兵庫県)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Interaction between glia and blood vessels during cortical development2015

    • Author(s)
      Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮(埼玉県)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Blood vessel-guided cell migration during late cortical plate development2015

    • Author(s)
      Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸(兵庫県)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Blood vessel-guided cell migration in the developing cerebral cortex2015

    • Author(s)
      Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
    • Organizer
      第48回日本発生生物学会大会
    • Place of Presentation
      つくば(茨城県)
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Functional screening of the candidate genes involving in the expansion of subventricular zone and the evolutionary analysis of them2015

    • Author(s)
      Hidenori Tabata, Tsuyoshi Hachiya, Koh-ichi Nagata, Yasubumi Sakakibara, Kazunori Nakajima
    • Organizer
      Cortical Evolution Conference 2015
    • Place of Presentation
      Toledo, Spain
    • Year and Date
      2015-05-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The unique migratory properties of glial progenitors derived from the cortical ventricular zone(皮質脳室帯由来グリア前駆細胞がとる特徴的な移動様式)2014

    • Author(s)
      Hidenori Tabata, Megumi Sasaki, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, Kazunori Nakajima
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] The migration of glial progenitors derived from the cortical ventricular zone2014

    • Author(s)
      Hidenori Tabata, Megumi Sasaki, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, Kazunori Nakajima
    • Organizer
      Cortical Development Conference 2014
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2014-05-22 – 2014-05-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional screening of the genes involved in the production of progenitor cells in the subventricular zone in mice2013

    • Author(s)
      Hidenori Tabata, Yasubumi Sakakibara, Koh-ichi Nagata, and Kazunori Nakajima
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, California, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳室下帯分裂細胞の産生調節に関わる分子の探索(Screening of the genes involving in the production of progenitor cells in the subventricular zone)2013

    • Author(s)
      田畑秀典、榊原康文、永田浩一、仲嶋一範
    • Organizer
      第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会(Neuro2013)
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Histological organization of mouse and primate subventricular zone in the developing cerebral neocortex2013

    • Author(s)
      Hidenori Tabata, Satoshi Yoshinaga, Yasubumi Sakakibara, Koh-ichi Nagata, Kazunori Nakajima
    • Organizer
      Neuro2013 Satellite Symposium “Molecular & Cellular Mechanisms of Brain Development & Evolution”
    • Place of Presentation
      Kyoto Prefecural University Library Hall, Kyoto
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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