| Project/Area Number |
25430047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
Hirato Junko 群馬大学, 医学部附属病院, 准教授 (60208832)
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| Co-Investigator(Kenkyū-buntansha) |
NOBUSAWA Sumihito 群馬大学, 医学系研究科, 助教 (80635318)
宮永 朋実 群馬大学, 医学部附属病院, 助教 (30455951)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYANAGA Tomomi 群馬大学, 医学部附属病院, 助教 (30455951)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 中枢神経系ラブドイド腫瘍 / INI1 / 混合型ラブドイド腫瘍 / 二次性非定型奇形腫様ラブドイド腫瘍 / 上皮様/ラブドイド膠芽腫 / array CGH / INI1,BRG1陽性胎児性腫瘍 / SWI/SNF complex / INI1, BRG1陽性胎児性腫瘍 / SMARCA2 / PBRM1 / 神経上皮性腫瘍 / ラブドイド細胞 / 非定型奇形腫様ラブドイド腫瘍 / epithelioid glioblastoma / epithelioid cell / BRAF / LSAMP |
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| Outline of Final Research Achievements |
There are several types of neuroepithelial tumors with rhabdoid cell components in the central nervous system. In these tumors atypical teratoid/rhabdoid tumor is an established tumor entity, but the classification of the others has not been performed appropriately. In the present study we analyzed several representative cases with rhabdoid tumors about the histopathological features and molecular genetic abnormalities using array CGH, DNA sequencing and FISH method. We verified that AT/RT arose from ependymoma, and found a novel specific gene alteration of epithelioid glioblastoma. These novel findings contributed to establish new entities like secondary AT/RT and epithelioid glioblastoma.
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