| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Lewy pathology occurs preferentially in systems with hyperbranching axon, where alpha-synuclein deposition occurs in distal axons. Because cardiac sympathetic nerve is affected early in Lewy body disorders, corresponding reduction in myocardial uptake of MIBG suggests the presence of Lewy body. Because Lewy pathology and corresponding clinical manifestations occur in whatever combination and sequence, we propose “Multifocal Lewy body disease” to account for their clinicopathological diversities. Neurofibrillary tangles of AD contain three-repeat and four-repeat tau. 4R tau deposition features early phase followed by replacement with 3R tau. This profile shift is initiated at dendrites and spreads towards neuronal soma. How 3R and 4R tau are related may be fundamental, which we are challenging by performing double-labelling immunoelectron microscopy with a novel technique. Preferential involvement of distal axons in Lewy body is in sharp contrast with dendritic involvement of AD-NFT.
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