Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
To investigate to a role of local protein synthesis during presynapse differentiation in neurons, we identified proteins that accumulate in axons during presynapse differentiation. Most of the identified proteins are derived from the target mRNA for FMRP (Fragile X Mental Retardation Proteins), the RNA-binding protein. Among these proteins, we examined Munc-18 accumulation during the presynapse differentiation. The accumulation time-course of Munc-18 corresponded to that of Argonaute2 (Ago2), which interacts with FMRP. Thus, it is possible that FMRP-Ago2 complex regulate Munc-18 expression via local protein synthesis during presynapse differentiation.
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