Analysis of molecular mechanisms establishing the circuit connectivity in the cerebellar afferent fibers
Project/Area Number |
25430073
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 神経回路 / シナプス結合 / 軸索伸展 / 遺伝子発現 / 神経回路形成 / シナプス / 軸索 / 小脳 |
Outline of Final Research Achievements |
We identified cadherin-7 (Cdh7) as a critical regulator of synaptic specificity in the cerebellar mossy fiber circuit between pontine nucleus neurons and cerebellar granule neurons. Cdh7 plays a dual role in target recognition and axonal growth termination to establish the specific synaptic connections in the cerebellar mossy fiber circuit. Several cadherin family members including Cdh7 are expressed in the cerebellar afferent fiber circuits (i.e. mossy fiber and climbing fiber) in a circuit-specific manner and the precise control of their expression is essential to the circuit connectivity. Through combinatorial analysis, some potential candidate regulators for the expression of those cadherins were identified.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis2013
Author(s)
Nishimoto, Y., Nakagawa, S., Hirose, T., Okano, H. J., Takao, M., Shibata, S., Suyama, S., Kuwako, K., Imai, T., Murayama, S., Suzuki, N., and Okano, H
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Journal Title
Mol. Brain
Volume: 6
Issue: 1
Pages: 31-31
DOI
Related Report
Peer Reviewed
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