Regulatory mechanisms for endocytosis of presynaptic molecules

Research Project

Project/Area Number	25430074
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurochemistry/Neuropharmacology
Research Institution	Keio University
Principal Investigator	Okuda Takashi 慶應義塾大学, 薬学部, 准教授 (00322040)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	小胞型トランスポーター / エンドサイトーシス / シグナル配列 / 小胞トランスポーター
Outline of Final Research Achievements	A novel assay was devised to search a signal sequence of the clathrin-mediated endocytosis. We found a novel endocytic signal sequence within the N-terminal region of the vesicular GABA transporter VGAT. VGAT is targeted to synaptic vesicles via the clathrin-mediated endocytosis pathway in which this signal sequence is involved.