Regulatory mechanisms for endocytosis of presynaptic molecules
Project/Area Number |
25430074
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Keio University |
Principal Investigator |
Okuda Takashi 慶應義塾大学, 薬学部, 准教授 (00322040)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 小胞型トランスポーター / エンドサイトーシス / シグナル配列 / 小胞トランスポーター |
Outline of Final Research Achievements |
A novel assay was devised to search a signal sequence of the clathrin-mediated endocytosis. We found a novel endocytic signal sequence within the N-terminal region of the vesicular GABA transporter VGAT. VGAT is targeted to synaptic vesicles via the clathrin-mediated endocytosis pathway in which this signal sequence is involved.
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Report
(4 results)
Research Products
(2 results)