| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Chronic consumption of ethanol has been reported to modify several molecular events in the central nervous system. In this study, chronic treatment with 3% ethanol for 5 days induced up-regulation of hormone-sensitive lipase (HSL) in ventral tegmental area (VTA) of mice. Moreover, phosphatidylinositol were also increased by chronic treatment with ethanol in VTA. Under the condition, the enhanced ethanol-induced place preference after chronic treatment with ethanol was significantly decreased by the intracerebroventricular administration of disulfiram. These results suggest that chronic treatment with ethanol induces amenability to excitation of the mesolimbic dopamine system, which is mediated by changed lipid metabolism. These changes induced by ethanol may influence the susceptibility to drug dependence.
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