Mechanisms of lipid metabolism system on neural plasticity in brain by ethanol
Project/Area Number |
25430076
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Hoshi University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | アルコール / 依存症 / 神経可塑性 / 脂質代謝 / モルヒネ |
Outline of Final Research Achievements |
Chronic consumption of ethanol has been reported to modify several molecular events in the central nervous system. In this study, chronic treatment with 3% ethanol for 5 days induced up-regulation of hormone-sensitive lipase (HSL) in ventral tegmental area (VTA) of mice. Moreover, phosphatidylinositol were also increased by chronic treatment with ethanol in VTA. Under the condition, the enhanced ethanol-induced place preference after chronic treatment with ethanol was significantly decreased by the intracerebroventricular administration of disulfiram. These results suggest that chronic treatment with ethanol induces amenability to excitation of the mesolimbic dopamine system, which is mediated by changed lipid metabolism. These changes induced by ethanol may influence the susceptibility to drug dependence.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.2015
Author(s)
Takasu K, Ogawa K, Nakamura A, Kanbara T, Ono H, Tomii T, Morioka Y, Hasegawa M, Shibasaki M, Mori T, Suzuki T, Sakaguchi G.
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Journal Title
Br J Pharmacol.
Volume: 172
Issue: 8
Pages: 2148-2164
DOI
Related Report
Peer Reviewed
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[Journal Article] G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.2014
Author(s)
Nakamura A, Fujita M, Ono H, Hongo Y, Kanbara T, Ogawa K, Morioka Y, Nishiyori A, Shibasaki M, Mori T, Suzuki T, Sakaguchi G, Kato A, Hasegawa M.
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Journal Title
Br J Pharmacol.
Volume: 171
Issue: 1
Pages: 253-264
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of opioid-induced rewarding effects under oxaliplatin- and Paclitaxel-induced neuropathy in rats.2014
Author(s)
Mori T, Kanbara T, Harumiya M, Iwase Y, Masumoto A, Komiya S, Nakamura A, Shibasaki M, Kanemasa T, Sakaguchi G, Suzuki T.
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Journal Title
J Pharmacol Sci.
Volume: 126
Pages: 47-55
NAID
Related Report
Peer Reviewed
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