Analysis and regulation of bi-directional changes in maturation status of brain cells utilising in vitro hightrokghput assay system
Project/Area Number |
25430077
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Fujita Health University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 細胞成熟度 / 海馬 / 歯状回 / 統合失調症 / うつ病 / モデルマウス / 精神疾患 / 神経細胞成熟度変化 / BDNF / 細胞成熟度異常 / 脳由来神経栄養因子 |
Outline of Final Research Achievements |
We sought to determine the molecular basis of the bi-directional changes in maturation status of brain cells, utilising primary mouse hippocampal (dentate gyrus) cultures as the in vitro hightrokghput assay system. Bioinformatics was also applied for the analysis and we identified several signal molecules that can be involved in the bi-directional changes. We next screened for biological conditions that are able to lead to the changes in cellular maturation status, identifying treatments of several chemicals that may induce the maturation status changes.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] マウス海馬歯状回における「過成熟」現象2015
Author(s)
Koshimizu H., Hagihara H., Ohira K., Keizo Takao K., Miyakawa T.
Organizer
第38回日本神経科学大会
Place of Presentation
神戸
Year and Date
2015-07-30
Related Report
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