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Effects of the modulation of the innate immunity and Dock family member on multiple sclerosis

Research Project

Project/Area Number 25430082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

GUO Xiaoli  公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員 (50443114)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsグリア細胞 / 多発性硬化症 / 視神経炎 / EAE / 細胞種特異的な遺伝子欠損マウス / ブリモニジン / 自然免疫 / candesartan
Outline of Final Research Achievements

We examined the effects of ASK1, one of the stress response genes, on the severity of the clinical score and optic neuritis in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Clinical signs of EAE were mild in glia-specific ASK1 conditional knockout mice. We also examined the effect of Dock8, an atypical guanine nucleotide exchange factor, on EAE, and found that optic neuritis was mild in Dock8 deficient mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 7 results,  Open Access: 4 results) Presentation (15 results) (of which Int'l Joint Research: 2 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] TrkB signaling in retinal glia stimulates neuroprotection after optic nerve injury.2015

    • Author(s)
      Harada, C., Azuchi, Y., Noro, T., Guo, X., Kimura, A., Namekata, K., Harada, T.
    • Journal Title

      American Journal of Pathology

      Volume: 185 Issue: 12 Pages: 3238-3247

    • DOI

      10.1016/j.ajpath.2015.08.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury.2015

    • Author(s)
      Noro, T., Namekata, K., Kimura, A., Guo, X., Azuchi, Y., Harada, C., Nakano, T., Tsuneoka, H. and Harada, T.
    • Journal Title

      Cell Death and Disease

      Volume: 6 Issue: 4 Pages: e1720-e1720

    • DOI

      10.1038/cddis.2015.93

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spermidine ameliorates neurodegeneration in a mouse model of normal tension glaucoma.2015

    • Author(s)
      Noro, T., Namekata, K., Azuchi, Y., Kimura, A., Guo, X., Harada, C., Nakano, T., Tsuneoka, H., Harada, T.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 56 Issue: 8 Pages: 5012-5019

    • DOI

      10.1167/iovs.15-17142

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Valproic acid prevents NMDA-induced retinal ganglion cell death via stimulation of neuronal TrkB receptor signaling2015

    • Author(s)
      Kimura, A., Namekata, K., Guo, X., Noro, T., Harada, C. and Harada, T.
    • Journal Title

      American Journal of Pathology

      Volume: 185 Issue: 3 Pages: 756-764

    • DOI

      10.1016/j.ajpath.2014.11.005

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma2015

    • Author(s)
      Kimura, A., Guo, X., Noro, T., Harada, C., Tanaka, K., Namekata, K. and Harada, T
    • Journal Title

      Neuroscience Letters

      Volume: 588 Pages: 108-113

    • DOI

      10.1016/j.neulet.2014.12.054

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brimonidine suppresses loss of retinal neurons and visual function in a murine model of optic neuritis2015

    • Author(s)
      Guo, X., Namekata, K., Kimura, A., Noro, T., Azuchi, Y., Semba, K., Harada, C., Yoshida, H., Mitamura, Y. and Harada, T.
    • Journal Title

      Neuroscience Letters

      Volume: 592 Pages: 27-31

    • DOI

      10.1016/j.neulet.2015.02.059

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Renin-angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma2015

    • Author(s)
      Semba, K., Namekata, K., Guo, X., Harada, C., Harada, T. and Mitamura, Y
    • Journal Title

      Cell Death and Disease

      Volume: 5 Issue: 7 Pages: e1333-e1333

    • DOI

      10.1038/cddis.2014.296

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.2013

    • Author(s)
      Namekata K, Kimura A, Kawamura K, Guo X, Harada C, Tanaka K, Harada, T.
    • Journal Title

      Cell Death and Differentiation

      Volume: 20 Issue: 9 Pages: 1250-1256

    • DOI

      10.1038/cdd.2013.91

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.2013

    • Author(s)
      Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
    • Journal Title

      Cell Death Differ.

      Volume: 20 Issue: 2 Pages: 270-280

    • DOI

      10.1038/cdd.2012.122

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Neuroprotection by valproic acid and spermidine in a mouse model of normal tension glaucoma2015

    • Author(s)
      Takayuki Harada, Atsuko Kimura, Takahiko Noro, Xiaoli Guo, Kazuhiko Namekata, Chikako Harada
    • Organizer
      45th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Brimonidine suppresses loss of retinal neurons and visual function in murine models of glaucoma and optic neuritis2015

    • Author(s)
      Xiaoli Guo, Kazuhiko Namekata, Atsuko Kimura, Takahiko Noro, Chikako Harada, Takayuki Harada
    • Organizer
      45th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Brimonidine protects retinal neurons and visual function in a murine model of optic neuritis2015

    • Author(s)
      Guo X., Namekata K., Kimura A., Noro T., Harada C., Harada T
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Brimonidine protects retinal neurons and visual function in a murine model of optic neuritis2015

    • Author(s)
      Xiaoli Guo
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌、札幌
    • Year and Date
      2015-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Dock3はERKシグナルを介して視神経の脱髄を抑制する2015

    • Author(s)
      行方和彦、郭暁麗
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌、札幌
    • Year and Date
      2015-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Dock3はERKシグナルを介して視神経の脱髄を抑制する2015

    • Author(s)
      行方和彦、木村敦子、郭 曉麗、原田知加子、原田高幸
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Spermidine stimulates neuroprotection and optic nerve regeneration following optic nerve injury2015

    • Author(s)
      Takahiko Noro, Xiaoli Guo
    • Organizer
      2015 Asia-ARVO (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2015-02-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Valproic acid protects retinal neurons from NMDA-induced neurotoxicity via stimulation of neuronal TrkB receptors2015

    • Author(s)
      Atsuko Kimura, Xiaoli Guo
    • Organizer
      2015 Asia-ARVO (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2015-02-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Dock8/10 regulate severity of inflammatory demyelination disorder2014

    • Author(s)
      Kazuhiko Namekata, Xiaoli Guo
    • Organizer
      The ARVO (The Association for Research in Vision and Ophthalmology) 2014 Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Combined inhibition of angiotensin II type 1 receptor and ASK1 significantly attenuates autoimmune optic neuritis2014

    • Author(s)
      Xiaoli Guo
    • Organizer
      The ARVO (The Association for Research in Vision and Ophthalmology) 2014 Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Inhibition of angiotensin II ameliorates autoimmune optic neuritis by suppressing innate immune responses2014

    • Author(s)
      Xiaoli Guo
    • Organizer
      World Ophthalmology Congress of the International Council of Ophthalmology (WOC) 2014
    • Place of Presentation
      Tokyo International Forum / Imperial Hotel, Tokyo
    • Year and Date
      2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Dock3 protects retinal neurons in a mouse model of normal tension glaucoma2014

    • Author(s)
      Kazuhiko Namekata, Xiaoli Guo
    • Organizer
      World Ophthalmology Congress of the International Council of Ophthalmology (WOC) 2014
    • Place of Presentation
      Tokyo International Forum / Imperial Hotel, Tokyo
    • Year and Date
      2014-04-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Interaction between renin-angiotensin and innate immune systems in autoimmune neuroinflammation

    • Author(s)
      Guo X
    • Organizer
      43rd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego、アメリカ
    • Related Report
      2013 Research-status Report
  • [Presentation] Dock8 is a therapeutic target for CNS inflammation

    • Author(s)
      Namekata K
    • Organizer
      43rd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego、アメリカ
    • Related Report
      2013 Research-status Report
  • [Presentation] Roles of ASK1 in neuroprotection and axonal regeneration after optic nerve injury

    • Author(s)
      Kittaka D
    • Organizer
      43rd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego、アメリカ
    • Related Report
      2013 Research-status Report
  • [Book] Neuroprotection and Neuroregeneration for Retinal Diseases2014

    • Author(s)
      Xiaoli Guo
    • Total Pages
      356
    • Publisher
      Springer Japan
    • Related Report
      2014 Research-status Report
  • [Book] Neuroprotection and Neuroregeneration for Retinal Diseases2014

    • Author(s)
      Guo X
    • Total Pages
      505
    • Publisher
      Springer Japan
    • Related Report
      2013 Research-status Report
  • [Remarks] 視覚病態プロジェクト

    • Related Report
      2015 Annual Research Report
  • [Remarks] 視覚病態プロジェクトホームページ

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 視神経保護剤2015

    • Inventor(s)
      原田高幸、行方和彦、郭 暁麗 他
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-30
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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