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human gene transgenic and knock-down rat model for HIV-1 infection

Research Project

Project/Area Number 25430084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionHokkaido University

Principal Investigator

shida Hisatoshi  北海道大学, 遺伝子病制御研究所, 客員教授 (00144395)

Co-Investigator(Kenkyū-buntansha) Zhang Xianfeng  北海道大学, 遺伝子病制御研究所, 助教 (40374681)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
KeywordsHIV-1 / 感染 / ラットモデル / ラット / 感染モデル
Outline of Final Research Achievements

To accelerate development of anti HIV-1 vaccine and therapeutics, a rat HIV-1 infection model is useful. We have already found macrophages of rats that express human CD4, CCR5, CyclinT1 and CRM1 genes are efficiently infected with HIV-1. Here we show that the rat T cells whose CyclophilinA and Apobec3 genes are knocked out allow HIV-1 propagation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All Other

All Remarks (1 results)

  • [Remarks] 北海道大学遺伝子病制御研究所感染病態分野

    • URL

      http://www.igm.hokudai.ac.jp/molvir

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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