human gene transgenic and knock-down rat model for HIV-1 infection
Project/Area Number |
25430084
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
|
Research Institution | Hokkaido University |
Principal Investigator |
shida Hisatoshi 北海道大学, 遺伝子病制御研究所, 客員教授 (00144395)
|
Co-Investigator(Kenkyū-buntansha) |
Zhang Xianfeng 北海道大学, 遺伝子病制御研究所, 助教 (40374681)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
Keywords | HIV-1 / 感染 / ラットモデル / ラット / 感染モデル |
Outline of Final Research Achievements |
To accelerate development of anti HIV-1 vaccine and therapeutics, a rat HIV-1 infection model is useful. We have already found macrophages of rats that express human CD4, CCR5, CyclinT1 and CRM1 genes are efficiently infected with HIV-1. Here we show that the rat T cells whose CyclophilinA and Apobec3 genes are knocked out allow HIV-1 propagation.
|
Report
(4 results)
Research Products
(1 results)