| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
In OC-Luc mice, expressing luciferase under the control human osteocalcin (OC) promoter, luminescence increased bimodally during pregnancy. TRAP activity and blood concentration of estrogen/progesterone showed positive correlation with luminescence increase during pregnancy. However, expression of endogenous mouse OC decreased and did not correlate with the rise of luminescence derived from OC-Luc during pregnancy. Luminescence derived from OC-Luc was also expressed in placenta, where no expression of mouse OC has been detected. These results show that human OC promoter was controlled differently from mouse OC promoter, suggesting that OC-Luc mice reflects the human OC expression during pregnancy.
|
