| Project/Area Number |
25430094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Tetsu 東海大学, 医学部, 教授 (10129744)
ENDO Hitoshi 東海大学, 医学部, 講師 (10550551)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMITA Masaru 慶應義塾大学, 環境情報学部, 教授 (60227626)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高次脳機能 / 高学習能モデル動物 / 学習 / 脳機能モデル動物 |
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| Outline of Final Research Achievements |
The higher brain function such as learning and memory is established by which many genes are developed the complicated transduction network. We attempted to identify the novel molecular regulation involved in the learning and memory through the use of unique rat strain Tokai High Avoider (THA), a high learning ability phenotype.
In the current study, we have suggested that immune system- and antioxidant function-related sets of genes are prominently involved in the phenotype of THA rats. We have demonstrated by principal component analysis of metabolites that Wistar and THA are a completely different strain. In addition, the levels of various amino acids are profoundly different from Wistar rats. These results suggested that the phenotype of THA rats is regulated by an intricate and unique molecular network.
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