| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We investigated whether IL-9 play an anti-melanoma activity in a RET-transgenic mouse, a spontaneous melanoma model. Previous study reported that IL-9 mediates tumor immunity to melanoma using a B16F10 mouse melanoma model. Our results indicated that in vivo administration of IL-9 did not suppress the spontaneous melanoma, though intratumoral accumulation of some granulocytes were observed. In addition, IL-9 also did not exert anti-tumor activity in a nude mice transplanted with B16F10. We concluded that administration of IL-9 failed to prevent a spontaneous melanoma progression in RET-transgenic mice, but IL-9 may potentiate anti-tumor activity mediated by T cell and granulocytes function.
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