Analysis of anti-tumor activity of interleukin-9 in melanoma models.
| Project/Area Number |
25430096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Chubu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | メラノーマ / IL-9 / ＩＬ－９ / マスト細胞 |
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| Outline of Final Research Achievements |
We investigated whether IL-9 play an anti-melanoma activity in a RET-transgenic mouse, a spontaneous melanoma model. Previous study reported that IL-9 mediates tumor immunity to melanoma using a B16F10 mouse melanoma model. Our results indicated that in vivo administration of IL-9 did not suppress the spontaneous melanoma, though intratumoral accumulation of some granulocytes were observed. In addition, IL-9 also did not exert anti-tumor activity in a nude mice transplanted with B16F10. We concluded that administration of IL-9 failed to prevent a spontaneous melanoma progression in RET-transgenic mice, but IL-9 may potentiate anti-tumor activity mediated by T cell and granulocytes function.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Actin-binding protein, espin: a novel metastatic regulator for melanoma.2014
Author(s)
Yanagishita, T., Yajima, I., Kumasaka, M., Kawamoto, Y., Tsuzuki, T., Matsumoto, Y., Watanabe, D., and Kato, M.
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Journal Title
Molecular cancer research
Volume: 12
Pages: 440-446
Related Report
Peer Reviewed
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