| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
A purpose of this study is to develop human allergy model using humanized mice. We evaluated human allergic responses by PCA reaction usinghumanized hIL-3/GM-CSF Tg mice, which can be fully differentiated human mast cells and basophils, after administration of the serum from pollinosis patients and pollen extract.Human mast cell-mediated allergic reaction efficientry developed in the skin of Tg mice but not of nonTg mice. Furthermore, we established novel humanized mice introduced hIL-5 gene into IL-3/GM Tg mice. In lungs of these triple-Tg mice, human eosinophils has infiltrated after intratracheal administration of HDM. Therefore, these humanized mice may contribute to develop the new anti-allergic drugs.
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