| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Transcription factor SOX17 has been shown to function as “tumor promoter” and also “tumor suppressor”, and the role of SOX17 in tumorigenesis has not yet been elucidated. In this project, the roles of SOX17 in intestinal tumor development and malignant progression with submucosal invasion have been examined by mouse genetic studies. We found that SOX17 expression is induced by Wnt signaling-dependent manner in tumor cells. However, disruption of SOX17 gene did not cause any morphological change of intestinal tumors. Moreover, the number, size, and invasion status of intestinal tumors were not changed by SOX17 disruption. These results indicate that SOX17 is dispensable for intestinal tumor development and malignant progression.
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