| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The naked mole-rat (NMR) is a long-living rodent with the maximum lifespan exceeding 30 years. Moreover, NMR has “senescence-resistant” and “cancer-resistant” phenotypes. In this study, to elucidate NMR’s “senescence-resistant” mechanisms at the cellular level, we subjected NMR skin fibroblasts to cellular senescence stimuli and compared their phenotypes with those of mouse. We found that NMR cells underwent cell death rather than cellular senescence. Moreover, we found the responsible gene for cell death in NMR cells after induction of cellular senescence. We also induced cellular senescence in skins of living NMRs. Compared to mice, we found that senescent cells were rarely detected in NMR’s skin.
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