Mechanisms of senescence-resistance of the naked mole-rat
| Project/Area Number |
25430116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Hokkaido University (2014-2015)
Keio University (2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIURA KYOKO 北海道大学, 遺伝子病制御研究所, 講師 (80583062)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ハダカデバネズミ / 細胞老化 / 細胞死 |
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| Outline of Final Research Achievements |
The naked mole-rat (NMR) is a long-living rodent with the maximum lifespan exceeding 30 years. Moreover, NMR has “senescence-resistant” and “cancer-resistant” phenotypes. In this study, to elucidate NMR’s “senescence-resistant” mechanisms at the cellular level, we subjected NMR skin fibroblasts to cellular senescence stimuli and compared their phenotypes with those of mouse. We found that NMR cells underwent cell death rather than cellular senescence. Moreover, we found the responsible gene for cell death in NMR cells after induction of cellular senescence. We also induced cellular senescence in skins of living NMRs. Compared to mice, we found that senescent cells were rarely detected in NMR’s skin.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Tumour resistance in induced pluripotent stem cells derived from naked mole-rats2016
Author(s)
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Yoshihiro Tsuchiya, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H & Miura K
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 11471-11471
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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