Functional analysis of tumor-associated macrophages accumulating in dead tumor cells
| Project/Area Number |
25430117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
NISHITAI GEN 東京薬科大学, 生命科学部, 助教 (60509941)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA MASATO 東京薬科大学, 生命科学部・免疫制御学研究室, 教授 (00294059)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マクロファージ / 遺伝子組換えマウス / 腫瘍免疫 |
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| Outline of Final Research Achievements |
Malignant tumors arise even in an immunocompetent host by maneuvering immune recognition. Accumulating evidence has suggested that tumor-associated macrophages play a key role in tumor growth. In the previous study, we revealed that CD204-positive macrophages were infiltrated to tumors in response to tumor cell death. To reveal the involvement of CD204-positive macrophages in tumor regrowth, we generated mice that contain human diphtheria toxin receptor (DTR) under the control of CD204 promoter. When CD204-positive macrophages were depleted by DT administration, tumor regrowth followed by X-ray irradiation was significantly suppressed. These results suggest that CD204-positive macrophages assist tumor regrowth.
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Report
(4 results)
Research Products
(2 results)
