| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Malignant tumors arise even in an immunocompetent host by maneuvering immune recognition. Accumulating evidence has suggested that tumor-associated macrophages play a key role in tumor growth. In the previous study, we revealed that CD204-positive macrophages were infiltrated to tumors in response to tumor cell death. To reveal the involvement of CD204-positive macrophages in tumor regrowth, we generated mice that contain human diphtheria toxin receptor (DTR) under the control of CD204 promoter. When CD204-positive macrophages were depleted by DT administration, tumor regrowth followed by X-ray irradiation was significantly suppressed. These results suggest that CD204-positive macrophages assist tumor regrowth.
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