| Project/Area Number |
25430123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Takamiya RIna 札幌医科大学, 医学部, 助教 (70365419)
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| Co-Investigator(Kenkyū-buntansha) |
Ohtsubo Kazuaki 熊本大学, 大学院生命科学研究部(保), 教授 (30525457)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 低酸素 / 糖鎖抗原 / マクロファージ / がん微小環境 / 酸化ストレス / がん |
|---|
| Outline of Final Research Achievements |
The expression of sialyl-Tn (sTn) antigen abnormally expresses in several types of cancers, is often related to poor prognosis and tumor metastasis. However, the relevance of the sTn antigen expression to tumor progression is yet to be determined. The expression of sTn-expressing tumor cells coincided with HIF-1 expressing cells in solid tumor tissues. Furthermore, macrophages and T cells partially infiltrated into solid tumor, where specifically expressed sTn antigen. In addition, sialyl-Tn antigen on integrin induced the adhesion of tumor cells to monocytes. These results suggest that sTn antigen may trigger tumor progression by modifying of immune microenvironment, especially macrophage function.
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