| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The Mieap-regulated mitochondrial quality control is inactivated in 50～70% tumors of colorectal, pancreatic, breast, gastric, and esophageal cancer patients. As the result, unhealthy mitochondria dramatically and specifically accumulated in the cancer cells in the in vivo tumor microenvironment. The cancer-specific unhealthy mitochondria produce high level of reactive oxygen species, leading to the enhanced activities of cancer migration and invasion under hypoxic conditions. These results suggest that the Mieap-regulated mitochondrial quality control has a critical role in tumor suppression in the in vivo hypoxic tumor microenvironment.
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