| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Invadopodia are membrane protrusions formed by invasive cancer cells that contain bundled actin filaments and mediate degradation of the extracellular matrix. Invadopodia are thought to promote cancer invasion. In this study, the function of actinin-4, an actin bundling protein implicated in cancer progression, in invadopodia formation was investigated. Actinin-4 localized at invadopodia and was required for the formation of actin structures and the extracellular matrix degradation activity of invadopodia. Overexpression of actinin-4 enhanced invadopodia formation and this activity required the actin bundling activity. These results indicate that actinin-4 bundles actin filaments at invadopodia and plays an important role in cancer invasion and metastasis.
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