| Project/Area Number |
25430128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Kondo Tadashi 国立研究開発法人国立がん研究センター, その他部局等, その他 (30284061)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Akira 国立がん研究センター, 中央病院, 医長 (90252965)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 転移性骨腫瘍 / 多層的オミクス解析 / バイオマーカー / プロテオミクス / miRNA / 臨床検体 |
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| Outline of Final Research Achievements |
All malignancies can cause bone metastasis, and many cancer patients have bone metastasis. To obtain the molecular insights of bone metastasis and develop clinical applications, we performed multi-OMICS study. Using tumor tissues of primary and bone metastatic legion, we compared the protein and miRNA expression in a global way. We identified differently expressed genes. The functional significances of identified genes were examined by in vitro gene silencing study, and confirmed that the specific inhibitors affected the growth of tumor cells, The protein with overexpressed level in bone metastasis was released from the tumor cells, and we measured it by specific antibody.
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