Development of new therapeutic strategy targeting epithelial-mesenchymal transition and sialyl lewis glycans
| Project/Area Number |
25430129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
Sakuma Keiichiro 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 (90402891)
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Masahiro 愛知県がんセンター(研究所), 分子病態学部, 部長 (60362464)
KANNAGI Reiji 愛知医科大学, 先端医学研究センター, 客員教授 (80161389)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上皮間葉転換 / 浸潤・転移 / がん / 転移 / シアリルルイス糖鎖 / 上皮間葉転換(EMT) |
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| Outline of Final Research Achievements |
The object of this study is to establish a new therapeutic strategy for colon cancer through elucidating the molecular mechanism underlying c-Myc-induced sialyl lewis glycan expression in colon cancer cells undergoing epithelial-mesenchymal transition (EMT). Identification of the EMT-specific modification of c-Myc have given no reproducible results, whereas the profiles of c-Myc-bound proteins and genes identified by NGS and ChIP-on-Chip were significantly different between EMT and non-EMT colon cancer cells, which is under detailed analysis. Our murine orthotopic colon cancer model has to be improved because it presented a technical problem due to necrosis of primary tumor making it difficult to identify cancer cell undergoing EMT.
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Report
(4 results)
Research Products
(8 results)
