| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The object of this study is to establish a new therapeutic strategy for colon cancer through elucidating the molecular mechanism underlying c-Myc-induced sialyl lewis glycan expression in colon cancer cells undergoing epithelial-mesenchymal transition (EMT). Identification of the EMT-specific modification of c-Myc have given no reproducible results, whereas the profiles of c-Myc-bound proteins and genes identified by NGS and ChIP-on-Chip were significantly different between EMT and non-EMT colon cancer cells, which is under detailed analysis. Our murine orthotopic colon cancer model has to be improved because it presented a technical problem due to necrosis of primary tumor making it difficult to identify cancer cell undergoing EMT.
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